Chemical Engineering / Kimya Mühendisliği

Permanent URI for this collectionhttps://hdl.handle.net/11147/14

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Acid-Catalyzed Degradation of Biomass With Hydrothermal Electrolysis for the Production of Value-Added Chemicals
(American Chemical Society, 2014) Yüksel, Aslı; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
[No abstract available]
Citation - WoS: 4
Citation - Scopus: 4
Adsorption Kinetics of Methane Reformer Off-Gases on Aluminum Based Metal-Organic Framework
(Elsevier Ltd., 2020) Angı, Deniz; Çakıcıoğlu Özkan, Seher Fehime; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Solvothermal synthesis of aluminum based metal-organic frameworks (MIL-53(Al)s) were conducted by considering the effects of crystallization and activation temperatures, and the solvent at purification step. Adsorption kinetics of Steam Methane Reformer off gas components at 34, 70 and 100 °C temperatures was measured by using ZLC method. Henry constant decreases as diffusion coefficient of the gases increases with increasing temperature; It was determined that the CO gas has the highest activation energy. Adsorption kinetics of gases were controlled with electrostatic interaction. © 2020 Hydrogen Energy Publications LLC
Advances in Nanocomposite Membranes for CO2 Removal
(Elsevier, 2024) Marpani,F.; Othman,N.H.; Alias,N.H.; Mat Shayuti,M.S.; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Nanocomposite membranes have emerged as a promising solution for efficient carbon dioxide (CO2) removal in gas separation processes. These membranes combine polymeric matrices with inorganic nanofillers to synergize the excellent separation performance of inorganic materials with the mechanical stability of polymers. The choice of nanofillers, such as porous and nonporous materials, significantly influences the gas permeability and selectivity of the resulting nanocomposite membranes. Porous fillers with interstitial channels and large surface areas are found to selectively adsorb CO2, enhancing membrane separation performance. On the other hand, nonporous fillers alter the polymer chain orientation, influencing gas separation differently. The 1D, 2D, and 3D morphologies of nanofillers offer unique properties in terms of surface-to-volume ratio, permeability, and selectivity. The fabrication of nanocomposite membranes also plays a crucial role, and advances in materials and manufacturing techniques have enabled the design of high-performing membranes. Asymmetric and symmetric configurations have been explored to optimize separation efficiency. Nevertheless, challenges such as aging, compaction, and swelling need to be addressed to ensure the long-term stability of nanocomposite membranes. Future research should focus on developing advanced theoretical models to better predict gas permeation behaviors in these membranes. Overall, nanocomposite membranes offer a promising avenue for efficient CO2 removal, contributing to sustainable environmental practices and energy production. © 2024 Elsevier Ltd. All rights reserved.
Aluminium-Coated Polymer Films as Infrared Light Shields for Food Packing
(Apple Academic Press, 2014) Hamrang, Abbas; Balköse, Devrim; Zaikov, Gennadij Efremovich; Haghi, A. K.; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
This book covers a broad range of polymeric materials and provides industry professionals and researchers in polymer science and technology with a single, comprehensive book summarizing all aspects involved in the functional materials production chain. This volume presents the latest developments and trends in advanced polymer materials and structures. It discusses the developments of advanced polymers and respective tools to characterize and predict the material properties and behavior. This book has an important role in advancing polymer materials in macro and nanoscale. Its aim is to provide original, theoretical, and important experimental results that use non-routine methodologies. It also includes chapters on novel applications of more familiar experimental techniques and analyses of composite problems that indicate the need for new experimental approaches. This new book: • Provides a collection of articles that highlight some important areas of current interest in key polymeric materials and technology. • Gives an up-to-date and thorough exposition of the present state of the art of key polymeric materials and technology. • Describes the types of techniques now available to the engineers and technicians and discusses their capabilities, limitations, and applications. • Provides a balance between materials science and chemical aspects, basic and applied research. • Focuses on topics with more advanced methods. • Emphasizes precise mathematical development and actual experimental details. • Explains modification methods for changing of different materials properties. © 2020 Elsevier B.V., All rights reserved.
Citation - WoS: 4
Citation - Scopus: 5
Antifouling Polydopamine-Modified Poly (ether Sulfone) Membrane Immobilized With Alumina-Calcium Oxide Catalyst for Continuous Biodiesel Production
(Elsevier, 2023) Güngörmüş, Elif; Şeker, Erol; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Biodiesel is an alternative biofuel that can be blended with conventional petroleum-derived diesel fuel to partly reduce the dependence on the imported oil. Catalytic membrane reactors are promising candidates for sustainable biodiesel production. Herein, we report a novel catalytically active polydopamine-modified poly (ether sulfone) (PES) membrane immobilized with an alumina-calcium oxide catalyst. The reaction temperature, butanol to canola oil ratio, and transmembrane pressure applied through the membrane were optimized with response surface methodology and Box-Behnken design. In contrast to all previous catalytic membrane studies for biodiesel production, we used butanol as a co-reactant to improve the winter problems of biodiesel made with methanol. FTIR and SEM-EDX analysis confirmed the successful immobilization of the catalyst. At the end of 30 days of storage in the reactant mixture, 95% of the catalyst loaded to the membrane was still on the surface, and biodiesel yield values and butanol flux of the membrane did not change. We compared the batch and flowthrough operation modes by measuring the catalytic activity of membranes under static and dynamic conditions within 24 h (8-cycle). The biodiesel yield under dynamic condition decreased in the first three cycles from 54.54 +/- 0.65% to 47.31 +/- 0.70% and then stayed constant, whereas a continuous decrease from 25.42 +/- 0.57% to 17.19 +/- 0.58% was observed under static condition. In each cycle, the equilibrium limitation for the yield was overcome only when the membrane was operated under pressure. The main reason for the decrease in catalytic activities was the fouling on the catalyst surface which was quickly removed by backwashing with butanol. It is concluded that catalytic membranes with antifouling properties and alcohol stability can make biodiesel production more cost-effective and environmentally friendly.
Citation - WoS: 32
Citation - Scopus: 36
Aptamer-Based Electrochemical Biosensing Strategy Toward Human Non-Small Cell Lung Cancer Using Polyacrylonitrile/Polypyrrole Nanofibers
(Springer, 2020) Kıvrak, Ezgi; İnce Yardımcı, Atike; İlhan, Recep; Ballar Kırmızıbayrak, Petek; Yılmaz, Selahattin; Kara, Pınar; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
In the present study, a sensitive electrochemical aptamer-based biosensing strategy for human non-small cell lung cancer (NSCLC) detection was proposed using nanofiber-modified disposable pencil graphite electrodes (PGEs). The composite nanofiber was comprised of polyacrylonitrile (PAN) and polypyrrole (PPy) polymers, and fabrication of the nanofibers was accomplished using electrospinning process onto PGEs. Development of the nanofibers was confirmed using scanning electron microscopy (SEM). The high-affinity 5 '-aminohexyl-linked aptamer was immobilized onto a PAN/PPy composite nanofiber-modified sensor surface via covalent bonding strategy. After incubation with NSCLC living cells (A549 cell line) at 37.5 degrees C, the recognition between aptamer and target cells was monitored by electrochemical impedance spectroscopy (EIS). The selectivity of the aptasensor was evaluated using nonspecific human cervical cancer cells (HeLa) and a nonspecific aptamer sequence. The proposed electrochemical aptasensor showed high sensitivity toward A549 cells with a detection limit of 1.2 x 10(3)cells/mL. The results indicate that our label-free electrochemical aptasensor has great potential in the design of aptasensors for the diagnostics of other types of cancer cells with broad detection capability in clinical analysis.
Citation - WoS: 2
Citation - Scopus: 2
Automated Deep Learning Model Development Based on Weight Sensitivity and Model Selection Statistics
(Pergamon-elsevier Science Ltd, 2025) Yalcin, Damla; Deliismail, Ozgun; Tuncer, Basak; Boy, Onur Can; Bayar, Ibrahim; Kayar, Gizem; Sildir, Hasan; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Current sustainable production and consumption processes call for technological integration with the realm of computational modeling especially in the form of sophisticated data-driven architectures. Advanced mathematical formulations are essential for deep learning approach to account for revealing patterns under nonlinear and complex interactions to enable better prediction capabilities for subsequent optimization and control tasks. Bayesian Information Criterion and Akaike Information Criterion are introduced as additional constraints to a mixed-integer training problem which employs a parameter sensitivity related objective function, unlike traditional methods which minimize the training error under fixed architecture. The resulting comprehensive optimization formulation is flexible as a simultaneous approach is introduced through algorithmic differentiation to benefit from advanced solvers to handle computational challenges and theoretical issues. Proposed formulation delivers 40% reduction, in architecture with high accuracy. The performance of the approach is compared to fully connected traditional methods on two different case studies from large scale chemical plants.
Citation - WoS: 50
Citation - Scopus: 57
Bioactive Fish Scale Incorporated Chitosan Biocomposite Scaffolds for Bone Tissue Engineering
(Elsevier Ltd., 2019-07) Kara, Aylin; Tamburacı, Sedef; Tıhmınlıoğlu, Funda; Havıtçıoğlu, Hasan; 03.02. Department of Chemical Engineering; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Recently, biologically active natural macromolecules have come into prominence to be used as potential materials in scaffold design due to their unique characteristics which can mimic the human tissue structure with their physical and chemical similarity. Among them, fish scale (FS) is a biologically active material with its structural similarity to bone tissue due to including type I collagen and hydroxyapatite and also have distinctive collagen arrangement. In the present study, it is aimed to design a novel composite scaffold with FS incorporation into chitosan (CH) matrix for bone tissue regeneration. Therefore, two biological macromolecules, fish scale and chitosan, were combined to produce bio-composite scaffold. First, FS were decellularized with the chemical method and disrupted physically as microparticles (100 in), followed by dispersal in CH with ultrasonic homogenisation, CH/FS scaffolds were fabricated by lyophilization technique. Scaffolds were characterized physically, chemically, mechanically, and morphologically. SEM and porosity results showed that CH/FS scaffolds have uniform pore structure showing high porosity. Mechanical properties and degradation rate are enhanced with increasing FS content. In vitro cytotoxicity, proliferation and osteogenic activity of the scaffolds were evaluated with SaOS-2 cell line. CH/FS scaffolds did not show any cytotoxicity effect and the cells were gradually proliferated during culture period. Cell viability results showed that, FS microparticles had a proliferative effect on SaOS-2 cells when compared to control group. ALP activity and biomineralization studies indicated that FS micro particle reinforcement increased osteogenic activity during culture period. As a biological macromolecule with unique characteristics, FS was found as cytocompatible and provided promising effects as reinforcement agents for polymeric scaffolds. In conclusion, fabricated CH/FS bio-composites showed potential for bone tissue engineering applications. (C) 2019 Elsevier B.V. All rights reserved.
Citation - WoS: 18
Citation - Scopus: 20
Bioactive Snail Mucus-Slime Extract Loaded Chitosan Scaffolds for Hard Tissue Regeneration: the Effect of Mucoadhesive and Antibacterial Extracts on Physical Characteristics and Bioactivity of Chitosan Matrix
(IOP Publishing, 2021) Perpelek, Merve; Tamburacı, Sedef; Aydemir, Selma; Tıhmınlıoğlu, Funda; Baykara, Başak; Karakaşlı, Ahmet; Havıtçıoğlu, Hasan; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Biobased extracts comprise various bioactive components and they are widely used in tissue engineering applications to increase bioactivity as well as physical characteristics of biomaterials. Among animal sources, garden snail Helix aspersa has come into prominence with its antibacterial and regenerative extracts and show potential in tissue regeneration. Thus, in this study, bioactive H. aspersa extracts (slime, mucus) were loaded in chitosan (CHI) matrix to fabricate porous scaffolds for hard tissue regeneration. Physical, chemical properties, antimicrobial activity was determined as well as in vitro bioactivity for bone and cartilage regeneration. Mucus and slime incorporation enhanced mechanical properties and biodegradation rate of CHI matrix. Scanning electron microscopy images showed that the average pore size of the scaffolds decreased with higher extract content. Mucus and slime extracts showed antimicrobial effect on two bacterial strains. In vitro cytotoxicity, osteogenic and chondrogenic activity of the scaffolds were evaluated with Saos-2 and SW1353 cell lines in terms of Alkaline phosphatase activity, biomineralization, GAG, COMP and hydroxyproline content. Cell viability results showed that extracts had a proliferative effect on Saos-2 and SW1353 cells when compared to the control group. Mucus and slime extract loading increased osteogenic and chondrogenic activity. Thus, the bioactive extract loaded CHI scaffolds showed potential for bone and cartilage regeneration with enhanced physical properties and in vitro bioactivity.
Citation - WoS: 4
Citation - Scopus: 4
Breakthrough Curve Analysis of Phosphorylated Hazelnut Shell Waste in Column Operation for Continuous Harvesting of Lithium From Water
(Elsevier, 2024) Recepoğlu, Yaşar Kemal; Arar, Ozguer; Yuksel, Asli; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
In batch-scale operations, biosorption employing phosphorylated hazelnut shell waste (FHS) revealed excellent lithium removal and recovery efficiency. Scaling up and implementing packed bed column systems necessitates further design and performance optimization. Lithium biosorption via FHS was investigated utilizing a continuous-flow packed-bed column operated under various flow rates and bed heights to remove Li to ultra-low levels and recover it. The Li biosorption capacity of the FHS column was unaffected by the bed height, however, when the flow rate was increased, the capacity of the FHS column decreased. The breakthrough time, exhaustion time, and uptake capacity of the column bed increased with increasing column bed height, whereas they decreased with increasing influent flow rate. At flow rates of 0.25, 0.5, and 1.0 mL/min, bed volumes (BVs, mL solution/mL biosorbent) at the breakthrough point were found to be 477, 369, and 347, respectively, with the required BVs for total saturation point of 941, 911, and 829, while the total capacity was calculated as 22.29, 20.07, and 17.69 mg Li/g sorbent. In the 1.0, 1.5, and 2.0 cm height columns filled with FHS, the breakthrough times were 282, 366, and 433 min, respectively, whereas the periods required for saturation were 781, 897, and 1033 min. The three conventional breakthrough models of the Thomas, Yoon-Nelson, and Modified Dose-Response (MDR) were used to properly estimate the whole breakthrough behavior of the FHS column and the characteristic model parameters. Li's extremely favorable separation utilizing FHS was evidenced by the steep S-shape of the breakthrough curves for both parameters flow rate and bed height. The reusability of FHS was demonstrated by operating the packed bed column in multi-cycle mode, with no appreciable loss in column performance.
Calcium Soap Lubricants
(CRC Press, 2015) İzer, Alaz; Kahyaoğlu, Tuğçe Nefise; Balköse, Devrim; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
The reparation and characterization of calcium stearate (CaSt2) and a lubricant by using calcium stearate were aimed at in this study. Calcium stearate powder was prepared from sodium stearate and calcium chloride by precipitation from aqueous solutions. CaSt2 and the Light Neutral Base oil were mixed together to obtain lubricating oil. It was found that CaSt2 had a melting temperature of 142.8 °C and in base oil it had a lower melting point, above 128 °C. It was dispersed as lamellar micelles as the optical micrographs had shown. From rate of settling the size of dispersed particles were found to be 1.88 µm and 0.11 µm for lubricants having 1% and 2% CaSt2, respectively. The friction coefficient and wear scar diameter of base oil 0.099 and 1402 nm were reduced to 0.0730 and 627.61 nm respectively for the lubricant having 1% CaSt2. Lower wear scar diameter (540 nm) was obtained for lubricant with 2% CaSt2. CaSt2 improved the lubricating property of the base oil but did not improve its oxidative and thermal stability. © 2015 by Apple Academic Press, Inc.
Calcium Soap Lubricants
(Apple Academic Press, 2015) İzer, Alaz; Kahyaoğlu, Tuğçe Nefise; Balköse, Devrim; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
The reparation and characterization of calcium stearate (CaSt2) and a lubricant by using calcium stearate were aimed at in this study. Calcium stearate powder was prepared from sodium stearate and calcium chloride by precipitation from aqueous solutions. CaSt2 and the Light Neutral Base oil were mixed together to obtain lubricating oil. It was found that CaSt2 had a melting temperature of 142.8 °C and in base oil it had a lower melting point, above 128 °C. It was dispersed as lamellar micelles as the optical micrographs had shown. From rate of settling the size of dispersed particles were found to be 1.88 ?m and 0.11 ?m for lubricants having 1% and 2% CaSt2, respectively. The friction coefficient and wear scar diameter of base oil 0.099 and 1402 nm were reduced to 0.0730 and 627.61 nm respectively for the lubricant having 1% CaSt2. Lower wear scar diameter (540 nm) was obtained for lubricant with 2% CaSt2. CaSt2 improved the lubricating property of the base oil but did not improve its oxidative and thermal stability. © 2015 by Apple Academic Press, Inc.
Citation - WoS: 50
Citation - Scopus: 60
Carbonaceous Materials for Removal and Recovery of Phosphate Species: Limitations, Successes and Future Improvement
(Pergamon-Elsevier Science Ltd, 2022) Recepoğlu, Yaşar Kemal; Gören, Ayşegül Yağmur; Orooji, Yasin; Khataee, Alireza; 03.07. Department of Environmental Engineering; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
The carbonaceous materials have gained significant interest for the phosphorus species remediation and recovery in the last decade. Carbonaceous materials present many unique features, such as cost effective, availability, environmentally friendly, and high removal efficiency that make them a promising adsorbent. In this review, the recent application of carbonaceous materials including activated carbon (AC), graphene and graphene oxide (GO), lignin, carbon nanotubes (CNTs), and gC(3)N(4) for phosphate removal and recovery were comprehensively summarized. The kinetics and isotherm models, removal mechanisms, and effects of operating parameters are reported. The reusability, lifetime of carbonaceous materials, and impact of modification were also considered. The modified carbonaceous materials have significantly high phosphate adsorption capacity compared to unmodified adsorbents. Namely, MgO-functionalized lignin-based bio-charcoal exhibited a 906.8 mg g(-1) of capacity as the highest one among other reviewed materials. The modification of carbonaceous materials with various elements has been presented to improve the surface functional groups, surface area and charge, and pore volume and size. Among these loaded elements, iron has been effectively used to provide a prospect for magnetic recovery of the adsorbent as well as increase phosphate adsorption. Furthermore, the phosphate recovery methods, phosphate removal efficiency of carbonaceous materials, the limitations, important gaps in the literature, and future studies to enhance applicability of carbonaceous materials in real scale are also discussed.
Control of the Particle Size and Purity of Nano Zinc Oxide
(Taylor & Francis, 2014) Özmıhçı Ömürlü, Filiz; Balköse, Devrim; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Effects of template, mechanical mixing and/or ultrasound mixing on the size of the ZnO crystals obtained by precipitation at 30 °C from aqueous zinc chloride and potassium hydroxide solutions were investigated by 2k factorial design. Precipitation method is employed to synthesize nano zinc oxide particles. Monodisperse nano ZnO having 29 nm particle size was produced by adding triethyl amine and applying simultaneously mechanical and ultrasound mixing. The surface area and the density of the powder were 21 m2/g and 4.8 g/cm3. It contains 5.2% impurities present as CO3-2 and bound OH- groups. Volumetric resistivity was found as 1.3 × 107ohm cm. Absorption spectrum of the powder showed absorption peak at 353 nm. The room temperature fluorescence spectrum of the powder revealed a strong and sharp UV emission band at 391 nm due to free exciton or bound exciton of ZnO and a weak and broad violet emission band at 405 nm due to zinc vacancies.
Citation - Scopus: 1
Data Driven Leak Detection in a Real Heat Exchanger in an Oil Refinery
(Elsevier, 2023) Yasmal, Aslı; Kuşoğlu Kaya, Gizem; Oktay, Emirhan; Çölmekci, Ceylan; Uzunlar, Erdal; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
This study focuses on implementation of a data-based leak detection method in a heat exchanger in a petroleum refinery. We have studied on the two real leakage cases in a heat exchanger in Izmit TUPRAS Refinery. Leaks are one of the major problems that occur in operations. The autoencoder (AE) method is implemented for leak detection. Reconstruction error is used as the leak indicator. In case of leakage, the reconstruction value is expected to increase. For both cases examined, the reconstruction error is found to be around 1-5 under normal operating conditions. On the other hand, reconstruction error is observed to change between 10 and 60 under the conditions with leakage. Besides, the AE is able to indicate the start of one leakage case before the process engineers noticed it. © 2023 Elsevier B.V.
Citation - WoS: 12
Citation - Scopus: 13
Development of Agcl-Tio2 Xerogels Entrapped Antibacterial Polyacrylonitrile Membranes: the Effect of High Salinity Water on Silver Release, Antibiofouling and Antibacterial Efficacies
(Elsevier Ltd., 2020) Uz, Metin; Yaşar Mahlıçlı, Filiz; Şeker, Erol; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Silver-containing antibacterial membranes are commonly used to control biofouling during bacteria filtration. Unfortunately, fast and uncontrolled release of silver to water is a challenge since this causes mass accumulation of silver in water resources and insufficient long-term antimicrobial effect. To overcome these disadvantages, we propose to add AgCl-TiO2 xerogels (0–0.8 wt%) in the polyacrylonitrile membranes. The long-term silver retaining of the membranes was evaluated by measuring the silver release under filtration of deionized water in the absence and the presence of 1 M NaCl up to 5 days. The antibiofouling and the antibacterial efficacies were determined by measuring the changes in antibacterial activity and DI water flux of the membranes at the end of 5 days of E. coli filtration. The 0.2 wt% AgCl-TiO2 xerogel incorporated polyacrylonitrile membrane demonstrated a constant ~1 ?g of silver release/cm2 per filtration cycle after a total filtration of 0.05 L/cm2 with 1 M NaCl solution. Additionally, it showed antibacterial efficacy and ~100% recovery of deionized water flux by simple backwashing with water after having been used in many E. coli filtration cycles. Thus, this membrane could potentially be used up to ~5.8 years for 8000 h a year for the filtration of high salinity water. Statement of novelty: Silver-containing antibacterial membranes are commonly used to control biofouling during bacteria filtration. Uncontrolled release of silver from the membrane causes massive silver accumulation in water which in turn leads to contamination of water resources and threat to aquatic organisms. Although silver release is strongly influenced by the salinity of water, the release data was collected through filtration of pure DI water or tap water in literature. To overcome the shortcomings of the published studies, we propose to use AgCl-TiO2 xerogels in membranes due to low solubility of AgCl in water and measure the release by filtering high-salinity water. © 2020 Elsevier B.V.
Development of Functional Materials for Sirna Delivery and Neural Tissue Engineering
(AIChE, 2015) Uz, Metin; Alsoy Altınkaya, Sacide; Mallapragada, Surya K.; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
The current nonviral siRNA delivery systems in the literature face many problems such as, cellular entry, endosomal escape and efficient siRNA release. Considering this motive, we developed gold nanoparticles (AuNPs) and temperature/pH responsive pentablock copolymer based siRNA delivery systems to address these problems. The temperature and pH responsive cationic and amphiphilic pentablock copolymers, which were consisted of the temperature responsive Pluronic F127 middle block constructed by PEO-PPO-PEO ((poly(ethyleneoxide)-block-poly(propyleneoxide)-block-poly(ethyleneoxide))) blocks contributing cellular entry through temperature responsive micellization and pH responsive cationic PDEAEM (poly(2-diethylaminoethyl methacrylate)) end blocks facilitating nucleic acid condensation and endosomal escape, were used for the first time in the development of polyplex and AuNP based multicomponent siRNA delivery systems (MCSs). The results indicated that systems managed to protect siRNA from external effects, maintain the system stability, facilitate cellular entry and enhance endosomal escape. It was noted that the transfection efficiency of the MCSs, which were boosted by the presence of cleavable disulfide bond, was ~15% higher than the commercial product RNAiMax while the efficacy of polyplexes alone were similar to the RNAiMax.
Citation - Scopus: 8
Editors’ Foreword
(CRC Press, 2017) Figoli, A.; Hoinkis, Jan; Altinkaya, Sacide Alsoy; Bundschuh, Jochen; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
The book focuses on Application of Nanotechnology in Membranes for Water Treatment but not only provides a series of innovative solutions for water reclamation through advanced membrane technology but also serves as a medium to promote international cooperation and networking for the development of advanced membrane technology for Universal well-being and to achieve the common goal of supplying economically, environmentally and societally sustainable freshwater and better sanitation systems. This book is unique because the chapters were authored by established researchers all around the globe based on their recent research findings. In addition, this book provides a holistic coverage of membrane development for water treatment, from the membrane preparation and characterizations to the performance for specific processes and applications. Since that water scarcity has become a global risk and one of the most serious challenges for the scientific community in this century, the publication of this book is therefore significant as it will serve as a medium for a good reference of an alternative solution in water reclamation. This book will provide the readers with a thorough understanding of the different available approaches for manufacturing membranes both with innovative polymeric systems and inorganic nano-materials which could give enhanced functionalities, catalytic and antimicrobial activities to improve the performance of the existing membranes. It will be useful for leading decision and policy makers, water sector representatives and administrators, policy makers from the governments, business leaders, business houses in water treatment, and engineers/ scientists from both industrialized and developing countries as well. © 2019 Elsevier B.V., All rights reserved.
Citation - WoS: 4
Citation - Scopus: 9
The Effect of Military Conflict Zone in the Middle East on Atmospheric Persistent Organic Pollutant Contamination in Its North
(Elsevier, 2023-06) Ayrı, İlknur; Genişoğlu, Mesut; Sofuoğlu, Aysun; Kurt Karakuş, Perihan B.; Birgül, Askın; Sofuoğlu, Sait Cemil; 03.02. Department of Chemical Engineering; 03.07. Department of Environmental Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
This study aimed to investigate long-range atmospheric transport of selected POPs released due to the effects of mili-tary conflicts in regions to the south of Turkey's borders. Ten locations were selected to deploy passive air samplers at varying distances to the border on a southeast-west transect of the country, proximity-grouped as close, middle, and far. Sampling campaign included winter and transition months when desert dust transport events occur. Hypothesis of the study was that a decreasing trend would be observed with increasing distance to the border. Group comparisons based on statistical testing showed that PBDE-183, E45PCB, and dieldrin in winter; PBDE-28, PBDE-99, PBDE-154, p,p '-DDE, E14PBDE, and E25OCP in the transition period; and PBDE-28, PBDE-85, PBDE-99, PBDE-154, PBDE-190, PCB-52, E45PCB, p,p '-DDE, and E25OCP over the whole campaign had a decreasing trend on the transect. An analysis of concen-tration ratio to the background showed that long-range atmospheric transport impacted the study sites, especially those of close group in comparison to the local sources. Back-trajectory analyses indicated that there was transport from the conflict areas to sites in the close-proximity group, while farther sampling locations mostly received air masses from Europe, Russia, and former Soviet Union countries, followed by North Africa, rather than the military con-flict areas. In consequence, decrease in concentrations with distance and its relation to molecular weight through pro-portions, diagnostic ratios, analysis of concentration ratio to the background, and back-trajectory analyses support the effect of transport from the military-conflict area to its north.
Citation - WoS: 24
Effect of pH and Hydration on the Normal and Lateral Interaction Forces Between Alumina Surfaces
(2006) Polat, Mehmet; Sato, Kimiyasu; Nagaoka, Takaaki; Watari, Koji; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.02. Department of Chemical Engineering
Normal and lateral interaction forces between alumina surfaces were measured using Atomic Force Microscopy-Colloid Probe Method at different pH. The normal force curves exhibit a well-defined repulsive barrier and an attractive minimum at acidic pH and the DLVO theory shows excellent agreement with the data. The normal forces are always repulsive at basic pH and the theory fails to represent the measurements. Lateral forces are almost an order of magnitude smaller in the basic solutions. These differences, which have important implications in the study of stability and rheology, are attributed to the hydration of the alumina surface at basic pH. © 2013 Elsevier B.V., All rights reserved.

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