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Bioengineering / Biyomühendislik

Permanent URI for this collectionhttps://hdl.handle.net/11147/4529

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Browsing Bioengineering / Biyomühendislik by Journal "2019 9th International Conference on Recent Advances in Space Technologies (RAST)"

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    Genetic Determinants of Musculoskeletal Adaptations To Unloading and Reloading
    (Institute of Electrical and Electronics Engineers Inc., 2019) Özçivici, Engin; Özçivici, Engin; Judex, Stefan; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Lack of weight bearing is one of the most critical limitations for long term health of bone tissue in space missions. In this study, we performed a series of Quantitative Trait Locus (QTL) analysis of musculoskeletal traits to define genomic modulators adaptations to mechanical unloading and subsequent reloading using a genetically heterogeneous (F2 BALBxC3H) female mouse population. The identified regions on genome contain genes that regulate musculoskeletal adaptations to weightlessness and further studies may help to categorize individuals that are at risk for greater tissue loss during weightlessness and/or low tissue recovery during reambulation.
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    Citation - WoS: 4
    Citation - Scopus: 7
    Lensless Digital In-Line Holographic Microscopy for Space Biotechnology Applications
    (Institute of Electrical and Electronics Engineers Inc., 2019) Delikoyun, Kerem; Anıl İnevi, Müge; Çine, Ersin; Delikoyun, Kerem; Anıl İnevi, Müge; Özçivici, Engin; Özuysal, Mustafa; Özuysal, Mustafa; Özçivici, Engin; Tekin, Hüseyin Cumhur; Tekin, Hüseyin Cumhur; 03.01. Department of Bioengineering; 03.04. Department of Computer Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Biomechanical changes at cellular level can dramatically affect living organisms in both aviation and space applications. Weightlessness induces morphological alteration of cells, which leads to tissue loss. Therefore, scientists have been studying the effect of weightlessness using cell culture based biological experiments using conventional microscopes. However, strict requirements regarding cost, weight and functionality limit the use of conventional microscopes in space environment. Lensless digital in-line holographic microscopy enables to use low-weight, low-cost and robust elements, such as a light emitting diode (LED), an aperture and an imaging sensor, instead of bulky, expensive and fragile optical elements, such as lenses, mirrors and filters. This technology offers a high field of view compared to conventional microscopes without affecting the resolution and it is also suitable for remote sensing applications with automated imaging capabilities. Here, we present a portable digital in-line holographic microscopy platform that allows to visualize cells and to analyze their viability in a microfluidic chip. The platform offers microscopic imaging with 1.55 mu m spatial resolution, 21.7 mm(2) field of view and image coloring capability. This platform could potentially play an important role in space biotechnology applications by enabling low-cost, high-resolution and portable monitoring of cells.