06. İYTE Araştırma Merkezleri / IZTECH Research Centers

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Citation - Scopus: 19
Application of Geothermal Energy and Its Environmental Problems in Turkey
(Inderscience Enterprises Ltd., 2015-09) Baba, Alper; Baba, Alper; 03.03. Department of Civil Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
Human beings have been benefiting from geothermal energy for different uses since the dawn of the civilisation in many parts of the world. One of the earliest uses of geothermal energy was for heating and it was used extensively by Romans in Turkey. The Aegean region is favoured by a large number of thermal springs known since ancient times. However, it was first in the 20th century that geothermal energy was used on a large scale for direct use and electricity generation. The country's installed heat capacity is 2,705 MWt for direct use and 322.39 MWe for power production. In parallel to developing geothermal energy applications in Turkey, many sites are now experiencing problems such as water contamination associated with geothermal fluid. Especially, the high temperature solution of elements and compounds, causes operational limitations in geothermal power plants. These limitations are due to the severe scaling and corrosion of geothermal fluid. Copyright © 2015 Inderscience Enterprises Ltd.
Citation - WoS: 3
Citation - Scopus: 4
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones
(Bentham Science Publishers, 2017) Çağır, Ali; Çağır, Ali; Odacı, Burcu; Varol, Mehmet; Akçok, İsmail; Okur, Özgür; Koparal, Ayşe T.; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.
Exergetic Analysis of a Continuous Bi-Axially Oriented Polypropylene (bopp) Film Unit in a Plastic Processing Plant
(Inderscience Enterprises Ltd., 2009) Balta, M. Tolga; Hancıoğlu, Ebru; Hepbaşlı, Arif; Hancıoğlu, Ebru; Özcanlı, Şevket Cihangir; Yılmazer, Ertan; Yurdakul, İbrahim; Dişbudak, Özgür; 01. Izmir Institute of Technology
This paper deals with an exergy analysis of the stretching process of bi-axially oriented polypropylene films using a hot oil coiler along with stretching and crystallising unit. Exergy destructions and efficiencies in each of the system components are calculated, while the exergy loss and flow diagram (the so-called Grassmann diagram) is presented for the transverse direction (TD) unit. The so-called functional (on the product or benefit/fuel basis) and universal (on the output/input basis) exergy efficiency values of the TD unit are calculated to be 26.40% and 28.46% at a recommended exhaust air relative humidity of 0.0098 kg water/kg air, respectively.
Citation - WoS: 8
Citation - Scopus: 8
Nkx3.1 Contributes To S Phase Entry and Regulates Dna Damage Response (ddr) in Prostate Cancer Cell Lines
(Academic Press Inc., 2011-10) Erbaykent Tepedelen, Burcu; Özmen, Besra; Varışlı, Lokman; Gönen Korkmaz, Ceren; Debeleç Bütüner, Bilge; Hamid, Syed Muhammad; Çakmak, Özgür Yılmazer; Korkmaz, Kemal Sami
NKX3.1 is an androgen-regulated homeobox gene that encodes a tissue-restricted transcription factor, which plays an important role in the differentiation of the prostate epithelium. Thus, the role of NKX3.1 as a functional topoisomerase I activity enhancer in cell cycle regulation and the DNA damage response (DDR) was explored in prostate cancer cell lines. As an early response to DNA damage following CPT-11 treatment, we found that there was an increase in the γH2AX (S139) foci number and that total phosphorylation levels were reduced in PC-3 cells following ectopic NKX3.1 expression as well as in LNCaP cells following androgen administration. Furthermore, upon drug treatment, the increase in ATM (S1981) phosphorylation was reduced in the presence of NKX3.1 expression, whereas DNA-PKcs expression was increased. Additionally, phosphorylation of CHK2 (T68) and NBS1 (S343) was abrogated by ectopic NKX3.1 expression, compared with the increasing levels in control PC-3 cells in a time-course experiment. Finally, NKX3.1 expression maintained a high cyclin D1 expression level regardless of drug treatment, while total γH2AX (S139) phosphorylation remained depleted in PC-3, as well as in LNCaP, cells. Thus, we suggest that androgen regulated NKX3.1 maintains an active DDR at the intra S progression and contributes to the chemotherapeutic resistance of prostate cancer cells to DNA damaging compounds.
Citation - WoS: 29
Citation - Scopus: 31
Performance investigation of the drying of parsley in a tray dryer system
(Inderscience Enterprises Ltd., 2010) Hancıoğlu, Ebru; Hancıoğlu, Ebru; Hepbaşlı, Arif; İçier, Filiz; Erbay, Zafer; Çolak, Neslihan; 01. Izmir Institute of Technology
The performance of a tray dryer system for the parsley drying process was assessed using energy and exergy analysis methods in this study. The drying temperature ranged from 40°C to 60°C, while the drying air velocity varied from 0.5 m/s to 1.5 m/s. The higher temperature and lower velocity led to higher exergy and energy efficiencies. The exergy efficiency value for the overall system on a product/fuel basis was found to be 3.62%. The values for Specific Moisture Extraction Rate (SMER) and Specific Moisture Exergetic index (SMExR) were obtained to be 0.08 and 2.47 kg/kWh, respectively. Copyright © 2010 Inderscience Enterprises Ltd.
Citation - WoS: 6
Citation - Scopus: 8
The Potential, Utilization and Development of Geothermal Energy in Türkiye
(Maden Tetkik ve Arama Genel Mudurlugu-mta, 2023) Sener, Mehmet Furkan; Uzelli, Taygun; Uzelli, Taygun; Baba, Alper; Akkus, Ibrahim; Mertoglu, Orhan; Baba, Alper; 03.03. Department of Civil Engineering; 01.01. Units Affiliated to the Rectorate; 01. Izmir Institute of Technology; 03. Faculty of Engineering
Geothermal energy is a natural resource that can be utilized directly or by converting to other types of energy. Considering the diversity of the geological structure of Turkiye, the geothermal systems have developed depending on young tectonic and volcanic active rock. Western and Central Anatolia are especially rich in geothermal resources. The geothermal well with the hottest well-bottom temperature was drilled in Central Anatolia, and the well-bottom temperature was measured as 341 degrees C at a depth of 3845 meters. In 2022, Turkiye's electricity generation capacity and the total installed direct heat use reached 1663 MWe and 5113 MWt, respectively. Considering Anatolia's Curie depth and heat flux, the probable thickness of the batholith can be regarded as 10 km. For example, the total granitoid area of Western Anatolia is 4221 km2 and at least 2% of this granitoid can provide approximately 8x107 MWh of electricity by Enhanced Deep Geothermal Systems (EDGS). When all granites in Turkiye are considered, it is expected that the future capacity of Turkiye will be much higher with drilling research and development studies and the discovery of new fields. This capacity will exceed 100.000 MWt levels in the medium term, especially with the addition of EDGSs.
Citation - WoS: 39
Citation - Scopus: 48
Prevalence and Antibiotic Resistance of Foodborne Staphylococcus Aureus Isolates in Turkey
(Mary Ann Liebert Inc., 2011-01-08) Aydın, Ali; Okuklu, Burcu; Muratoğlu, Karlo; Harsa, Hayriye Şebnem; Sudağıdan, Mert; Bostan, Kamil; Okuklu, Burcu; Harsa, Şebnem; 03.08. Department of Food Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
In this study, 154 Staphylococcus aureus isolates were detected from 1070 food samples (14.4%) collected from seven cities in Turkey. Antimicrobial susceptibility testing against 21 antibiotics was performed by agar disk diffusion method, and those isolates resistant to any antibiotic were further analyzed to determine minimum inhibitory concentration by E-test and polymerase chain reaction analysis of vanA and mecA genes. According to disk diffusion test results, a total of 139 strains were resistant to at least one tested antibiotic, with 39 (25.3%) strains being multidrug resistant (MDR) and the other 15 strains being susceptible to all antibiotics. Penicillin G, linezolid, erythromycin, and tetracycline took up 71.4%, 23.4%, 18.2%, and 15.6% of the tested strains, respectively. In addition, all of the strains were susceptible to vancomycin, oxacillin, cefoxitin, and imipenem. Only one strain (S158B) was resistant to both teicoplanin and cefazolin. On the other hand, the presence of vanA and mecA genes was not detected in the strains. Pulsed-field gel electrophoresis analysis was used to identify genetic-relatedness of the MDR strains. It is noteworthy that some strains from different sources showed 100% homology; however, some of MDR strains were found unrelated with 60% or less homology. The high diversity observed in pulsed-field gel electrophoresis results indicated the possible contamination of S. aureus from different sources and routes.

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