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06. İYTE Araştırma Merkezleri / IZTECH Research Centers

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Browsing 06. İYTE Araştırma Merkezleri / IZTECH Research Centers by Subject "B-cell"

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    Prognostic Significance of the Igvh Mutation Status and Immunohistochemical Analysis of Zap70 and Cd38 in Bone Marrow Biopsies in Chronic Lymphocytic Leukemia
    (Türkiye Klinikleri Journal of Medical Sciences, 2014) Kahraman Çetin, Nesibe; Kaçar Döger, Füruzan; Kurtgöz, Serkan Erkan; Rusçuklu, Dane; Yavaşoğlu, İrfan
    Objective: Chronic lymphocytic leukemia (CLL) is one of the most common leukemia type among adults in the industrialized countries. Due to the nature of CLL, it is important to recognize patients with a more rapid course of disease. The goal of our study was to study ZAP70 and CD38 antibodies along with immunglobulin heavy chain variable region (IgVH) mutation status, which have been associated with rapid progression and aggressive clinical course in CLL, and to correlate the expression of these molecules with patterns of bone marrow infiltration. Material and Methods: We included 84 bone marrow biopsy samples into the study to determine ZAP70 and CD38 status using immunohistochemistry. Expression patterns for both antibodies were then correlated with the bone marrow infiltration patterns. We also analyzed IgVH mutations in 20 patients using DNA obtained from paraffin-embedded formalin-fixed bone marrow biopsies. These findings were then correlated with immunohistochemical results. Results: We identified a positive correlation between the expression patterns of ZAP70 and CD38, factors that were previously identified as poor prognostic factors (p<0.001). However, there was no correlation between these two markers and IgVH mutation status (p=1.000 and p=0.931). In addition, we showed a statistically significant positive correlation with ZAP70 immunostaining, and the necessity for an early intervention (p=0.046). ZAP70 and CD38 expressions were statistically significantly correlated with the diffuse pattern infiltration of bone marrow (p<0.001 and p<0.001, respectively). Conclusion: Despite small number of our patients, the findings of our study suggested that ZAP70 and CD38 expression patterns as well as IgVH mutation status might be helpful to determine the course of the disease, and the risk of progression. Particularly ZAP70 immunopositive patients appear to have a faster disease progression, and may require earlier intervention and a closer follow up.