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Title: Hidrofobik ilaç taşıyıcısı olarak akrilik yıldız blok kopolimerler
Other Titles: Acrylic star block copolymers as hydrophobic drug carriers
Authors: Genç, Gözde
Batıgün, Ayşegül
Bayraktar, Oğuz
Altıntaş, Özcan
Tunca, Ümit
Hizal, Gürkan
Issue Date: 2009
Publisher: Institute of Electrical and Electronics Engineers Inc.
Abstract: Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by Atomic Transfer Radical Polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.
Description: 14th National Biomedical Engineering Meeting
ISBN: 978-1-4244-3605-7
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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