Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10122
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dc.contributor.authorAdan Gökbulut, Aysun-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2021-01-24T18:32:25Z-
dc.date.available2021-01-24T18:32:25Z-
dc.date.issued2014-
dc.identifier.issn0145-2126-
dc.identifier.urihttps://hdl.handle.net/11147/10122-
dc.description5th International Eurasian Hematology Congressen_US
dc.description.abstractAcute Promyelocytic Leukaemia (APL) is characterized by abnormal accumulation of immature granulocytes in the bone marrow and the blood stream. To date, there is no definitive treatment strategy. Fisetin, hesperetin and vitexin are flavanoids found in fruits and vegetables. Their anticancer properties have been studied on several cancer types. In this study, we aimed to examine the cytotoxic, cytostatic and apoptotic effects of fisetin, hesperetin and vitexin on Acute Promyelocytic Leukaemia cells. Cytotoxic effects were evaluated by MTT assay while apoptotic effects of these flavonoids were examined by changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and Annexin V/PI double staining. Cytostatic effects of the flavonoids were evaluated by propidium iodide staining using flow cytometry.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofLeukemia Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCytotoxic and apoptotic effects of fisetin, hesperetin and vitexinon acute promyelocytic leukemia cellsen_US
dc.typeConference Objecten_US
dc.institutionauthorGökbulut, Aysun Adan-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume38en_US
dc.identifier.startpageS46en_US
dc.identifier.endpageS46en_US
dc.identifier.wosWOS:000347244200108en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeConference Object-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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