Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10200
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dc.contributor.authorTüncel, Özge-
dc.contributor.authorKahraman, Erkan-
dc.contributor.authorBağcı, Gülsün-
dc.contributor.authorAtabey, Neşe-
dc.contributor.authorÖzçelik, Serdar-
dc.date.accessioned2021-01-24T18:32:55Z-
dc.date.available2021-01-24T18:32:55Z-
dc.date.issued2021-
dc.identifier.issn0928-4931-
dc.identifier.issn1873-0191-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2020.111585-
dc.identifier.urihttps://hdl.handle.net/10200-
dc.description.abstractEngineered silica nanoparticles (SiNP) are emerging materials for medical applications. Evaluating biological responses of specific cells treated with engineered silica nanoparticles is however essential. We synthesized and characterized the physicochemical properties of silica nanoparticles with two different sizes of 10 and 100 nm (10SiNP and 100SiNP) dispersed in cell culture medium. HuH-7, an epithelial-like human hepatoblastoma cell line and SK-HEP-1, a liver sinusoidal endothelial cell line (LSEC) are employed to evaluate their biological responses for the SiNP treatment. Primary human lymphocytes are used to assess genotoxicity recommended by OECD guidelines while erythrocytes are used to assess hemolytic activity. The engineered silica nanoparticles are not able to produce radical species, to alter the mitochondrial membrane potential, and induce any adverse effects on cell proliferation. The colony formation ability of HuH-7 hepatoblastoma cells was not affected following the SiNP treatment. Furthermore, SiNPs do not induce hemolysis of red blood cells and are not genotoxic. These findings suggest that SiNPs regardless of the size, amount, and incubation time are biologically safe vehicles to deliver drugs or genes to the liver. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipThis work was supported by the Izmir Institute of Technology [grant number 2012IYTEBAP06 ].en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell-cycleen_US
dc.subjectColony formationen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectHemolysisen_US
dc.subjectLiveren_US
dc.subjectLiver canceren_US
dc.subjectMitochondrial membrane potentialsen_US
dc.subjectSilica nanoparticlesen_US
dc.titleEngineered silica nanoparticles are biologically safe vehicles to deliver drugs or genes to liver cellsen_US
dc.typeArticleen_US
dc.institutionauthorTüncel, Özge-
dc.institutionauthorÖzçelik, Serdar-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume119en_US
dc.identifier.wosWOS:000600872000003en_US
dc.identifier.scopus2-s2.0-85092228392en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.msec.2020.111585-
dc.identifier.pmid33321631en_US
dc.relation.doi10.1016/j.msec.2020.111585en_US
dc.coverage.doi10.1016/j.msec.2020.111585en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ2-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextembargo_20240101-
item.languageiso639-1en-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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