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https://hdl.handle.net/11147/10206
Title: | Boosting up printability of biomacromolecule based bio-ink by modulation of hydrogen bonding pairs | Authors: | Köksal, Büşra Önbaş, Rabia Başkurt, Mehmet Şahin, Hasan Arslan Yıldız, Ahu Yıldız, Ümit Hakan |
Keywords: | 3D Scaffold Bioink Bioprinting Gelatin Hydrogel Tissue engineering |
Publisher: | Elsevier Ltd. | Abstract: | This study describes low dose UV curable and bioprintable new bioink made of hydrogen bond donor-acceptor adaptor molecule 2-isocyanatoethyl methacrylate (NCO)modified gelatin (NCO-Gel). Our theoretical calculations demonstrate that insertion of 2-isocyanatoethyl methacrylate doubles the interaction energy (500 meV) between gelatin chains providing significant contribution in interchain condensation and self-organization as compared to methacrylic anhydride modified gelatin (GelMA). The NCO-Gel exhibits peak around 1720 cm?1 referring to bidentate hydrogen bonding between H-NCO and its counterpart O[dbnd]CN[sbnd]H. These strong interchain interactions drive chains to be packed and thereby facilitating UV crosslinking. The NCO-Gel is exhibiting a rapid, 10 s gelation process by the exposure of laser (3 W, 365 nm). The dynamic light scattering characterization also reveals that NCO-Gel has faster sol to gel transition as compared to GelMA depending on the UV curing time. The NCO-Gel was found to be more firm and mechanically strong that provides advantages in molding as well as bioprinting processes. Bioprinted NCO-Gel has shown sharp borders and stable 3D geometry as compared to GelMA ink under 10 s UV curing time. The cell viability tests confirm that NCO-Gel facilitates cell proliferation and supports cell viability. We foresee that NCO-Gel bioink formulation provides a promising opportunity when low dose UV curing and rapid printing are required. © 2020 Elsevier Ltd | URI: | https://doi.org/10.1016/j.eurpolymj.2020.110070 https://hdl.handle.net/11147/10206 |
ISSN: | 0014-3057 |
Appears in Collections: | Bioengineering / Biyomühendislik Chemistry / Kimya Photonics / Fotonik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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1-s2.0-S0014305720317845-main.pdf | 9.68 MB | Adobe PDF | View/Open |
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