Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10223
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dc.contributor.authorArıca, Tuğçe A.-
dc.contributor.authorGüzelgülgen, Meltem-
dc.contributor.authorYıldız, Ahu Arslan-
dc.contributor.authorDemir, Mustafa Muammer-
dc.date.accessioned2021-01-24T18:33:04Z-
dc.date.available2021-01-24T18:33:04Z-
dc.date.issued2021-
dc.identifier.issn0928-4931-
dc.identifier.issn1873-0191-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2020.111720-
dc.identifier.urihttps://hdl.handle.net/10223-
dc.description.abstractThe development of biocompatible and transparent three-dimensional materials is desirable for corneal tissue engineering. Inspired from the cornea structure, gelatin methacryloyl-poly(2-hydroxymethyl methacrylate) (GelMA-p(HEMA)) composite hydrogel was fabricated. GelMA fibers were produced via electrospinning and covered with a thin layer of p(HEMA) in the presence of N,N?-methylenebisacrylamide (MBA) as cross-linker by drop-casting. The structure of resulting GelMA-p(HEMA) composite was characterized by spectrophotometry, microscopy, and swelling studies. Biocompatibility and biological properties of the both p(HEMA) and GelMA-p(HEMA) composite have been investigated by 3D cell culture, red blood cell hemolysis, and protein adsorption studies (i.e., human serum albumin, human immunoglobulin and egg white lysozyme). The optical transmittance of the GelMA-p(HEMA) composite was found to be approximately 70% at 550 nm. The GelMA-p(HEMA) composite was biocompatible with tear fluid proteins and convenient for cell adhesion and growth. Thus, as prepared hydrogel composite may find extensive applications in future for the development of corneal tissue engineering as well as preparation of stroma of the corneal material. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipIYTE 0322en_US
dc.description.sponsorshipThis work was supported by the Izmir Institute of Technology Scientific Research Project [grant number IYTE 0322 ]. Freeze drying and microscopy studies were carried out at the Izmir Institute of Technology Biotechnology and Bioengineering Application and Research Center and Materials Research Center, respectively. The authors thank Prof. Dr. M. Yakup Arica for contact angle measurements and fruitful discussions.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomaterialen_US
dc.subjectCell adhesion and growthen_US
dc.subjectCompositesen_US
dc.subjectHydrogelsen_US
dc.subjectProtein adsorptionen_US
dc.titleElectrospun GelMA fibers and p(HEMA) matrix composite for corneal tissue engineeringen_US
dc.typeArticleen_US
dc.institutionauthorArıca, Tuğçe A.-
dc.institutionauthorGüzelgülgen, Meltem-
dc.institutionauthorYıldız, Ahu Arslan-
dc.institutionauthorDemir, Mustafa Muammer-
dc.departmentİzmir Institute of Technology. Materials Science and Engineeringen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000617983800002en_US
dc.identifier.scopus2-s2.0-85096606879en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.msec.2020.111720-
dc.identifier.pmid33545871en_US
dc.relation.doi10.1016/j.msec.2020.111720en_US
dc.coverage.doi10.1016/j.msec.2020.111720en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ2-
dc.identifier.wosqualityttpTop10%en_US
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextembargo_20240101-
item.languageiso639-1en-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.09. Department of Materials Science and Engineering-
Appears in Collections:Bioengineering / Biyomühendislik
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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