Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10367
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dc.contributor.authorBulduk, İbrahim-
dc.contributor.authorAydın, Beyza Sultan-
dc.date.accessioned2021-01-24T18:34:14Z-
dc.date.available2021-01-24T18:34:14Z-
dc.date.issued2020-
dc.identifier.issn1307-6183-
dc.identifier.urihttps://doi.org/10.25135/jcm.41.20.04.1622-
dc.identifier.urihttps://hdl.handle.net/11147/10367-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/386864-
dc.description.abstractDonepezil HCl is a hydrochloride salt of a piperidine derivative acetylcholinesterase inhibitor and, it uses in treatment demantia of Alzheimer’s disease. In this study, a sensitive and rapid HPLC-UV method was developed and validated for determination of Donepezil HCl in API and tablet dosage forms. Chromatographic separation was performed using a Ace 5 C18 (5 ?m, 250 x 4.6 mm) by using isocratic phosphate buffer at pH:2.0 and acetonitrile (55:45, v/v) mobile phase was used at the rate of 1.2 mL/min. The column temperature was set at 30 ?C and the UV detection was recorded at 268 nm. The method was validated with respect to specificity, precision, accuracy, linearity, repeatability and reproducibility parameters in a concentration range of 25-125 µg/mL. The limit of detection (LOD) and limit of quantification (LOQ) were determined as 1.40 and4.20 µg/mL, respectively. The uncertainty budget of the measurement for Donepezil HCl was estiamted as 5.80 % at 95% confidence level (k = 2).en_US
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofJournal of Chemical Metrologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDonepezil HClen_US
dc.subjectPharmaceuticalsen_US
dc.subjectMethod validationen_US
dc.titleSimple high-performance liquid chromatographic method for determination of Donepezil HCl in pharmaceutical formulationsen_US
dc.typeArticleen_US
dc.institutionauthorAydın, Beyza Sultan-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.startpage69 - 76en_US
dc.identifier.wosWOS:000560662700008en_US
dc.identifier.scopus2-s2.0-85098088470en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.25135/jcm.41.20.04.1622-
dc.relation.doi10.25135/jcm.41.20.04.1622en_US
dc.coverage.doi10.25135/jcm.41.20.04.1622en_US
dc.identifier.trdizinid386864en_US
dc.identifier.scopusquality--
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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