Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10386
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dc.contributor.authorSarıgil, Öyküen_US
dc.contributor.authorAnıl İnevi, Mügeen_US
dc.contributor.authorFıratlıgil Yıldırır, Burcuen_US
dc.contributor.authorÜnal, Yağmur Cerenen_US
dc.contributor.authorYalçın Özuysal, Özdenen_US
dc.contributor.authorMeşe, Gülistanen_US
dc.contributor.authorÖzçivici, Enginen_US
dc.date.accessioned2021-01-24T18:34:26Z-
dc.date.available2021-01-24T18:34:26Z-
dc.date.issued2021-03en_US
dc.identifier.issn0006-3592-
dc.identifier.issn1097-0290-
dc.identifier.urihttps://doi.org/10.1002/bit.27631-
dc.identifier.urihttps://hdl.handle.net/10386-
dc.descriptionPubMed: 33205833en_US
dc.description.abstractTissue engineering research aims to repair the form and/or function of impaired tissues. Tissue engineering studies mostly rely on scaffold-based techniques. However, these techniques have certain challenges, such as the selection of proper scaffold material, including mechanical properties, sterilization, and fabrication processes. As an alternative, we propose a novel scaffold-free adipose tissue biofabrication technique based on magnetic levitation. In this study, a label-free magnetic levitation technique was used to form three-dimensional (3D) scaffold-free adipocyte structures with various fabrication strategies in a microcapillary-based setup. Adipogenic-differentiated 7F2 cells and growth D1 ORL UVA stem cells were used as model cells. The morphological properties of the 3D structures of single and cocultured cells were analyzed. The developed procedure leads to the formation of different patterns of single and cocultured adipocytes without a scaffold. Our results indicated that adipocytes formed loose structures while growth cells were tightly packed during 3D culture in the magnetic levitation platform. This system has potential for ex vivo modeling of adipose tissue for drug testing and transplantation applications for cell therapy in soft tissue damage. Also, it will be possible to extend this technique to other cell and tissue types.en_US
dc.description.sponsorshipTurkiye Bilimler Akademisi, Grant/Award Number: Young Investigator Award; Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 215S862en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofBiotechnology and Bioengineeringen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipose tissueen_US
dc.subjectBone marrow stem cellsen_US
dc.subjectMagnetic levitationen_US
dc.subjectTissue engineeringen_US
dc.subjectSingle cell studiesen_US
dc.titleScaffold-free biofabrication of adipocyte structures with magnetic levitationen_US
dc.typeArticleen_US
dc.authorid0000-0002-1207-1653en_US
dc.authorid0000-0003-2854-3472en_US
dc.authorid0000-0001-8716-542Xen_US
dc.authorid0000-0001-8736-8251en_US
dc.authorid0000-0003-0552-368Xen_US
dc.authorid0000-0003-0458-8684en_US
dc.authorid0000-0002-5758-5439en_US
dc.authorid0000-0003-4464-0475en_US
dc.institutionauthorSarıgil, Öykü-
dc.institutionauthorAnıl İnevi, Müge-
dc.institutionauthorFıratlıgil Yıldırır, Burcu-
dc.institutionauthorÜnal, Yağmur Ceren-
dc.institutionauthorYalçın Özuysal, Özden-
dc.institutionauthorMeşe, Gülistan-
dc.institutionauthorÖzçivici, Engin-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000593116600001en_US
dc.identifier.scopus2-s2.0-85096869177en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/bit.27631-
dc.identifier.pmid33205833en_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.doi10.1002/bit.27631en_US
dc.coverage.doi10.1002/bit.27631en_US
dc.description.volume118en_US
dc.description.issue3en_US
dc.description.startpage1127en_US
dc.description.endpage1140en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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