Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10389
Title: Biocomposite scaffolds for 3D cell culture: Propolis enriched polyvinyl alcohol nanofibers favoring cell adhesion
Authors: Bilginer, Rumeysa
Özkendir İnanç, Dilce
Yıldız, Ümit Hakan
Arslan Yıldız, Ahu
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Keywords: 3D cell culture
Biomimetic
Electrospinning
Propolis
Tissue engineering
Issue Date: May-2021
Publisher: John Wiley and Sons Inc.
Abstract: The objective of this work is generation of propolis/polyvinyl alcohol (PVA) scaffold by electrospinning for 3D cell culture. Here, PVA used as co-spinning agent since propolis alone cannot be easily processed by electrospinning methodology. Propolis takes charge in maximizing biological aspect of scaffold to facilitate cell attachment and proliferation. Morphological analysis showed size of the electrospun nanofibers varied between 172-523 nm and 345-687 nm in diameter, for non-crosslinked and crosslinked scaffolds, respectively. Incorporation of propolis resulted in desired surface properties of hybrid matrix, where hybrid scaffolds highly favored protein adsorption. To examine cell compatibility, NIH-3T3 and HeLa cells were seeded on propolis/PVA hybrid scaffold. Results confirmed that integration of propolis supported cell adhesion and cell proliferation. Also, results indicated electrospun propolis/PVA hybrid scaffold provide suitable microenvironment for cell culturing. Therefore, developed hybrid scaffold could be considered as potential candidate for 3D cell culture and tissue engineering.
URI: https://doi.org/10.1002/app.50287
https://hdl.handle.net/10389
ISSN: 0021-8995
1097-4628
Appears in Collections:Bioengineering / Biyomühendislik
Chemistry / Kimya
Photonics / Fotonik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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