Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11139
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dc.contributor.authorPolat, Hürriyet-
dc.contributor.authorÇevik Eren, Merve-
dc.contributor.authorPolat, Mehmet-
dc.date.accessioned2021-11-02T09:08:22Z-
dc.date.available2021-11-02T09:08:22Z-
dc.date.issued2021-12-
dc.identifier.issn0927-7757-
dc.identifier.urihttps://hdl.handle.net/11147/11139-
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2021.127712-
dc.description.abstractPolymeric micelles are promising delivery vehicles for improving the efficacy of anticancer drugs and reducing their side effects. However, considering the binding ability of serum albumin, the possible interaction of micelles with the native plasma components in the bloodstream raises serious questions on micellar stability. The stability of barren or drug-loaded copolymeric micelles was investigated systematically in distilled water (DW) and simulated body fluid (SBF) solutions in the presence of a model protein. The copolymer was a Pluronic® series triblock copolymer (P-123), the drug was strongly lipophilic docetaxel (DOC) and the protein was Bovine Serum Albumin (BSA). The effect of such factors as BSA and DOC concentrations and the aging of the micellar solutions was studied. Both the barren and drug-loaded micelles were quite stable in blank DW and SBF solutions for long times up to 10 days. They lost integrity and showed no inclination to re-assemble when the BSA concentration reached a critical value, which was very close to the plasma Human Serum Albumin (HSA) concentration. The presence of DOC in the micellar cores could not prevent disintegration. The results illustrate clearly that ensuring the stability of polymeric micelles in blood plasma should be an important design factor in their use as drug carriers.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspectsen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDocetaxelen_US
dc.subjectDrug carrieren_US
dc.subjectMicellesen_US
dc.subjectPolymeric surfactantsen_US
dc.titleThe Effect of Protein Bsa on the Stability of Lipophilic Drug (docetaxel)-Loaded Polymeric Micellesen_US
dc.typeArticleen_US
dc.authorid0000-0002-1573-0351-
dc.authorid0000-0002-1546-0013-
dc.institutionauthorPolat, Hürriyet-
dc.institutionauthorÇevik Eren, Merve-
dc.institutionauthorPolat, Mehmet-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.wosWOS:000711381100002-
dc.identifier.scopus2-s2.0-85117245323-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.colsurfa.2021.127712-
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn0927-7757en_US
dc.description.volume631en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept04.01. Department of Chemistry-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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