Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11287
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dc.contributor.authorÇeçen, Berivan-
dc.contributor.authorKaravasili, Christina-
dc.contributor.authorNazir, Mubashir-
dc.contributor.authorBhusal, Anant-
dc.contributor.authorDoğan, Elvan-
dc.contributor.authorShahriyari, Fatemeh-
dc.contributor.authorTamburacı, Sedef-
dc.contributor.authorMiri, Amir K.-
dc.date.accessioned2021-11-06T09:27:16Z-
dc.date.available2021-11-06T09:27:16Z-
dc.date.issued2021-
dc.identifier.issn1999-4923-
dc.identifier.urihttp://doi.org/10.3390/pharmaceutics13101657-
dc.identifier.urihttps://hdl.handle.net/11147/11287-
dc.description.abstractOrgan-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipThis research was funded by National Institutes of Health (NIH, R21DC018818) and New Jersey Institute of Technology (NJIT, Start-Up funding) awarded to A.K.M.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-throughput screeningen_US
dc.subjectMicrofluidicsen_US
dc.subjectMulti-organ-on-a-chipen_US
dc.subjectSmall drugsen_US
dc.titleMulti-organs-on-chips for testing small-molecule drugs: Challenges and perspectivesen_US
dc.typeArticleen_US
dc.institutionauthorTamburacı, Sedef-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume13en_US
dc.identifier.issue10en_US
dc.identifier.wosWOS:000714080800001en_US
dc.identifier.scopus2-s2.0-85117517588en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.3390/pharmaceutics13101657-
dc.identifier.pmid34683950en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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