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Title: A vacuum-integrated centrifugal microfluidic chip for density-based separation of microparticles
Authors: Öksüz, Cemre
Tekin, Hüseyin Cumhur
Keywords: Centrifugal microfluidics
Density-based separation
Sample loading
Issue Date: 2021
Publisher: IEEE
Abstract: Here we present a new vacuum-integrated centrifugal microfluidic chip for the density-based separation of microparticles. A sample was loaded in a fluidic channel using the gas permeability feature of polydimethylsiloxane (PDMS) membrane between fluidic and control channels. Vacutun was applied from control channel to drive a density media and then the sample containing microparticles in the dead-end fluidic channel. Afterwards, the chip was disconnected from the vacuum and it was centrifugated. If the sample contains microparticles denser than the density media, the microparticles are sedimented at the end of the microfluidic channel so that these particles can be separated from remaining the lower density particles. With this approach, we separated 1.09 g/mL microparticles with 82,6% efficiency and 99% purity from 1.02 g/mL microparticles. Separated particles in the microfluidic chip can also be inspected under a microscope for further analysis. This simple approach offers high efficient density-based separation of microparticles with close densities.
Description: 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) -- JAN 25-29, 2021 -- ELECTR NETWORK -- IEEE, IEEE MEMS Tech Community
ISBN: 978-1-6654-1912-3
ISSN: 1084-6999
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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