Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11425
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dc.contributor.authorKarakuzu, Betül-
dc.contributor.authorGülmez, Yekta-
dc.contributor.authorTekin, H. Cumhur-
dc.date.accessioned2021-11-06T09:48:31Z-
dc.date.available2021-11-06T09:48:31Z-
dc.date.issued2021-
dc.identifier.issn0167-9317-
dc.identifier.issn1873-5568-
dc.identifier.urihttps://doi.org/10.1016/j.mee.2021.111583-
dc.identifier.urihttps://hdl.handle.net/11147/11425-
dc.description.abstractRapid and portable analysis of arsenic (As) contamination in drinking water is very important due to its adverse health effects on humans. Available commercial detection kits have shown low sensitivity and selectivity in analysis, and also they can generate harmful by-products. Microfluidic-based approaches allow portable analysis with gold nanoparticles (AuNPs) as labels. However, they need complex surface modification steps that complicate detection protocols. Due to the lack of precise sensing and affordable solution, we focused on developing a microfluidic platform that uses a push-and-pull pumping method for sensitive detection of As. In this detection principle, a sample is introduced in the microfluidic channel modified with -SH functional groups where As can bind. Then, AuNPs are given in the channel and AuNPs bind on free -SH functional groups which are not allocated with As. Absorbance measurements are conducted to detect AuNPs absorbed on the surfaces and the resulting absorbance value is inversely proportional with As concentration. The method enables detection of As down to 2.2 mu g/L concentration levels in drinking water, which is well-below the allowed maximum As concentration of 10 mu g/L in the drinking waters by the World Health Organization (WHO). The paper reveals that multiple push-and-pull pumping of fixed volume of sample and AuNPs with a syringe pump can improve the binding efficiency in the microfluidic channel. With this technique, low amounts of sample (1 mL) and short total assay time (25 min) are sufficient to detect As.en_US
dc.description.sponsorshipThe authors acknowledge financial support from The Scientific and Technological Research Council of Turkey (grant number 217S518). H. C.T. would like to thank Outstanding Young Scientists Award funding (TUBA GEBIP 2020) from the Turkish Academy of Science. B.K. acknowledge the support of Turkish Council of Higher Education for 100/2000 CoHE doctoral scholarship. The authors would like to thank Engin Ozcivici, Ph.D. and Volga Bulmus, Ph.D. from the Department of Bioengineering, Izmir Institute of Technology (IZTECH) for helpful discussions. The authors would like to thank also Metin Tanoglu, Ph.D. from the Department of Mechanical Engineering, IZTECH for his support on contact angle measurements and IZTECH Biotechnology and Bioengineering Application and Research Center (BIYOMER) for FTIR analyses.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicroelectronic Engineeringen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrofluidic chipen_US
dc.subjectArsenic detectionen_US
dc.subjectPush-and-pull pumpingen_US
dc.subjectGold nanoparticlesen_US
dc.titleAbsorbance-based detection of arsenic in a microfluidic system with push-and-pull pumpingen_US
dc.typeArticleen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume247en_US
dc.identifier.wosWOS:000683446300003en_US
dc.identifier.scopus2-s2.0-85108090866en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.mee.2021.111583-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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