Please use this identifier to cite or link to this item:
https://hdl.handle.net/11147/11429
Title: | Sialidase neu4 deficiency is associated with neuroinflammation in mice | Authors: | Timur, Zehra Kevser İnci, Orhan Kerim Akyıldız Demir, Seçil Seyrantepe, Volkan |
Keywords: | Sialidases Neu4 Gangliosides Neuroinflammation Behavior |
Publisher: | Springer | Abstract: | Sialidases catalyze the removal of sialic acid residues from glycoproteins, oligosaccharides, and sialylated glycolipids. Sialidase Neu4 is in the lysosome and has broad substrate specificity. Previously generated Neu4-/- mice were viable, fertile and lacked gross morphological abnormalities, but displayed a marked vacuolization and lysosomal storage in lung and spleen cells. In addition, we showed that there is an increased level of GD1a ganglioside and a markedly decreased level of GM1 ganglioside in the brain of Neu4-/- mice. In this study, we further explored whether sialidase Neu4 deficiency causes neuroinflammation. We demostrated that elevated level of GD1a and GT1b is associated with an increased level of LAMP1-positive lysosomal vesicles and Tunel-positive neurons correlated with alterations in the expression of cytokines and chemokines in adult Neu4-/- mice. Astrogliosis and microgliosis were also significantly enhanced in the hippocampus, and cerebellum. These changes in brain immunity were accompanied by motor impairment in these mice. Our results indicate that sialidase Neu4 is a novel mediator of an inflammatory response in the mouse brain due to the altered catabolism of gangliosides. | URI: | https://doi.org/10.1007/s10719-021-10017-9 https://hdl.handle.net/11147/11429 |
ISSN: | 0282-0080 1573-4986 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Timur2021_Article.pdf | 6.28 MB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
3
checked on Sep 1, 2024
WEB OF SCIENCETM
Citations
3
checked on Aug 3, 2024
Page view(s)
12,442
checked on Sep 2, 2024
Download(s)
50
checked on Sep 2, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.