Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11558
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dc.contributor.authorYavuz, Süleyman Tolga-
dc.contributor.authorÖksel Karakuş, Ceyda-
dc.contributor.authorCustovic, Adnan-
dc.contributor.authorKalaycı, Ömer-
dc.date.accessioned2021-11-06T09:54:39Z-
dc.date.available2021-11-06T09:54:39Z-
dc.date.issued2021-
dc.identifier.issn0905-6157-
dc.identifier.issn1399-3038-
dc.identifier.urihttps://doi.org/10.1111/pai.13605-
dc.identifier.urihttps://hdl.handle.net/11147/11558-
dc.description.abstractBackground Childhood allergic rhinitis (AR) is clinically heterogenous. We aimed to identify distinct phenotypes among children with AR using data-driven techniques and to ascertain their association with patterns of symptoms, allergic sensitization, and comorbidities. Methods We recruited 510 children with physician-diagnosed AR, of whom 205 (40%) had asthma. Latent class analysis (LCA) was performed to identify latent structure within the data set using 17 variables (allergic conjunctivitis, eczema, asthma, family history of asthma, family history of allergic rhinitis, skin sensitization to 8 common allergens, tonsillectomy, adenoidectomy). Results A four-class solution was selected as the optimal model based on statistical fit. We labeled latent classes as: (1) AR with grass mono-sensitization and conjunctivitis (n = 361, 70.8%); (2) AR with house dust mite sensitization and asthma (n = 75, 14.7%); (3) AR with pet and grass polysensitization and conjunctivitis (n = 35, 6.9%); and (4) AR among children with tonsils and adenoids removed (n = 39, 7.6%). Perennial AR was significantly more common among children in Class 2 (OR 5.83, 95% CI 3.42-9.94, p < .001) and Class 3 (OR 2.88, 95% CI 1.36-6.13, p = .006). Mild and intermittent AR symptoms were significantly more common in children in Class 2 compared to those in Class 1. AR was more severe in Class 1 compared to other 3 classes, indicating that upper respiratory symptoms are more severe among children with isolated seasonal rhinitis, than in those with rhinitis and coexisting asthma. Conclusion We have identified 4 phenotypes in school-age children with AR, which were associated with different patterns of clinical symptoms and comorbidities.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Allergy and Immunologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergic rhinitisen_US
dc.subjectAllergyen_US
dc.subjectAsthmaen_US
dc.subjectChildrenen_US
dc.subjectPhenotypeen_US
dc.titleFour subtypes of childhood allergic rhinitis identified by latent class analysisen_US
dc.typeArticleen_US
dc.institutionauthorÖksel Karakuş, Ceydatr
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000681249300001en_US
dc.identifier.scopus2-s2.0-85111762408en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr
dc.identifier.doi10.1111/pai.13605-
dc.identifier.pmid34310772en_US
local.message.claim2023-01-26T12:04:33.631+0300|||rp03006|||submit_approve|||dc_contributor_author|||None*
dc.authorwosidOksel, Ceyda/AAS-5372-2020-
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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