Please use this identifier to cite or link to this item:
Title: Antiviral microRNA expression signatures are altered in subacute sclerosing panencephalitis
Authors: Tüfekçi, Kemal Uğur
Allmer, Jens
Çarman, Kürşat Bora
Bayram, Erhan
Topçu, Yasemin
Hız, Semra
Genç, Şermin
Yiş, Uluç
Keywords: Antiviral microRNA
Measles virus
Subacute sclerosing panencephalitis
Issue Date: 2021
Publisher: Wolters Kluwer Medknow Publications
Abstract: Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease caused by a persistent infection of the measles virus. Despite extensive efforts, the exact neurodegeneration mechanism in SSPE remains unknown. MicroRNAs (miRNAs) have emerged as an essential part of cellular antiviral defense mechanisms and can be modulated by antiviral cytokines Such as interferon-beta (IFN-beta). Aims and Objectives: In this study, we aimed to elucidate the role of antiviral miRNAs in the pathogenesis of SSPE and analyze the interaction between host antiviral miRNAs and virus genes. Materials and Methods: Thirty-seven patients who were followed with SSPE and age-matched healthy children were included in the study. Peripheral blood mononuclear cell levels of miR-196b, miR-296, miR-431, and miR-448 were analyzed using quantitative polymerase chain reaction. Target predictions and pathway constructions of deregulated miRNAs were assessed. Results: Here, we showed that IFN-beta-modulated miR-196b, miR-296, and miR-431 were significantly upregulated in patients with SSPE compared with healthy controls. Besides, sequence complementarity analysis showed that miR-296 and miR-196b predicted binding regions in measles virus genomic RNA. Conclusion: Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could be a part of the host antiviral defense mechanism. </p>
ISSN: 2636-865X
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
NeurolSciNeurophysiol383166-3389069_092450.pdf1.27 MBAdobe PDFView/Open
Show full item record

CORE Recommender

Page view(s)

checked on Dec 4, 2023


checked on Dec 4, 2023

Google ScholarTM



Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.