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https://hdl.handle.net/11147/11564
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DC Field | Value | Language |
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dc.contributor.author | Duman, Seda | - |
dc.contributor.author | Ekiz, Güner | - |
dc.contributor.author | Yılmaz, Sinem | - |
dc.contributor.author | Yusufoğlu, Hasan | - |
dc.contributor.author | Ballar Kırmızıbayrak, Petek | - |
dc.contributor.author | Bedir, Erdal | - |
dc.date.accessioned | 2021-11-06T09:54:40Z | - |
dc.date.available | 2021-11-06T09:54:40Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.issn | 1090-2120 | - |
dc.identifier.uri | https://doi.org/10.1016/j.bioorg.2021.104708 | - |
dc.identifier.uri | https://hdl.handle.net/11147/11564 | - |
dc.description.abstract | Cycloastragenol [20(R),24(S)-epoxy-3 beta,6 alpha,16 beta,25-tetrahydroxycycloartane] (CA), the principle sapogenol of many cycloartane-type glycosides found in Astragalus genus, is currently the only natural product in the anti-aging market as telomerase activator. Here, we report biotransformation of 20(27)-octanor-cycloastragenol (1), a thermal degradation product of CA, using Astragalus species originated endophytic fungi, viz. Penicillium roseopurpureum, Alternaria eureka, Neosartorya hiratsukae and Camarosporium laburnicola. Fifteen new biotransformation products (2-16) were isolated, and their structures were established by NMR and HRESIMS. Endophytic fungi were found to be capable of performing hydroxylation, oxidation, ring cleavage-methyl migration, dehydrogenation and Baeyer-Villiger type oxidation reactions on the starting compound (1), which would be difficult to achieve by conventional synthetic methods. In addition, the ability of the metabolites to increase telomerase activation in Hekn cells was evaluated, which showed from 1.08 to 12.4-fold activation compared to the control cells treated with DMSO. Among the compounds tested, 10, 11 and 12 were found to be the most potent in terms of telomerase activation with 12.40-, 7.89- and 5.43-fold increase, respectively (at 0.1, 2 and 10 nM concentrations, respectively). | en_US |
dc.description.sponsorship | This project was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 114Z958) . We are very grateful to Bionorm Natural Products for donating the substrate, and special thanks are due to the NMR spectrometer operator, Anzarulhaque Anwarulhaque, of Prince Sattam bin Abdulaziz University, AlKharj, Saudi Arabia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Academic Press | en_US |
dc.relation | Astragalus Sikloartanlarının Endofitik Funguslarla Biyotransformasyonu ve Elde Edilen Metabolitlerin Telomeraz Aktivasyonu Üzerine Etkilerinin Araştırılması | - |
dc.relation.ispartof | Bioorganic Chemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Saponins | en_US |
dc.subject | Cycloastragenol | en_US |
dc.subject | Endophytic fungi | en_US |
dc.subject | Fungal biotransformation | en_US |
dc.subject | Telomerase activation | en_US |
dc.subject | Potent metabolites | en_US |
dc.title | Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0002-6189-1818 | - |
dc.authorid | 0000-0002-7006-8030 | - |
dc.department | İzmir Institute of Technology. Bioengineering | en_US |
dc.identifier.volume | 109 | en_US |
dc.identifier.wos | WOS:000636137300010 | en_US |
dc.identifier.scopus | 2-s2.0-85101170744 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.bioorg.2021.104708 | - |
dc.identifier.pmid | 33621779 | en_US |
dc.relation.grantno | 114Z958 | - |
dc.authorwosid | Kirmizibayrak, Petek Ballar/Y-6869-2018 | - |
dc.identifier.wosquality | Q1 | - |
dc.identifier.scopusquality | Q1 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 01.01. Units Affiliated to the Rectorate | - |
crisitem.author.dept | 03.01. Department of Bioengineering | - |
Appears in Collections: | Bioengineering / Biyomühendislik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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1-s2.0-S0045206821000845-main.pdf | 828.23 kB | Adobe PDF | View/Open |
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