Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11580
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dc.contributor.authorRudzinska, Magdalenaen_US
dc.contributor.authorDağlıoğlu, Cenken_US
dc.contributor.authorSavvateeva, Lyudmila, Ven_US
dc.contributor.authorKaci, Fatma Necmiyeen_US
dc.contributor.authorAntoine, Rodolpheen_US
dc.contributor.authorZamyatnin, Andrey A., Jr.en_US
dc.date.accessioned2021-11-06T09:54:42Z-
dc.date.available2021-11-06T09:54:42Z-
dc.date.issued2021-
dc.identifier.issn1177-8881-
dc.identifier.urihttps://doi.org/10.2147/DDDT.S285852-
dc.identifier.urihttps://hdl.handle.net/11147/11580-
dc.description.abstractIn cancer treatments, many natural and synthetic products have been examined; among them, protease inhibitors are promising candidates for anti-cancer agents. Since dysregulated proteolytic activities can contribute to tumor development and metastasis, antagonization of proteases with tailored inhibitors is an encouraging approach. Although adverse effects of early designs of these inhibitors disappeared after the introduction of next-generation agents, most of the proposed inhibitors did not pass the early stages of clinical trials due to their nonspecific toxicity and lack of pharmacological effects. Therefore, new applications that modulate proteases more specifically and serve their programmed way of administration are highly appreciated. In this context, nanosized drug delivery systems have attracted much attention because preliminary studies have demonstrated that the therapeutic capacity of inhibitors has been improved significantly with encapsulated formulation as compared to their free forms. Here, we address this issue and discuss the current application and future clinical prospects of this potential combination towards targeted protease-based cancer therapy.en_US
dc.description.sponsorshipThis research was funded by the Russian Science Foundation (grant #16-15-10410).en_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development And Therapyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProteasesen_US
dc.subjectinhibitorsen_US
dc.subjectNanoscale drug-delivery systemen_US
dc.subjectCombination therapyen_US
dc.subjectCancer treatmenten_US
dc.titleCurrent status and perspectives of protease inhibitors and their combination with nanosized drug delivery systems for targeted cancer therapyen_US
dc.typeArticleen_US
dc.authorid0000-0002-3046-4565en_US
dc.authorid0000-0003-1795-7610en_US
dc.authorid0000-0003-3745-8173en_US
dc.institutionauthorDağlıoğlu, Cenken_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume15en_US
dc.identifier.startpage9en_US
dc.identifier.endpage20en_US
dc.identifier.wosWOS:000605660500001en_US
dc.identifier.scopus2-s2.0-85099838261-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2147/DDDT.S285852-
dc.identifier.pmid33442233-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
dc.identifier.wosqualityttpTop10%en_US
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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