Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11887
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dc.contributor.authorBayram, Nazende Nuren_US
dc.contributor.authorUlu, Gizem Tuğçeen_US
dc.contributor.authorTopuzoğulları, Muraten_US
dc.contributor.authorBaran, Yusufen_US
dc.contributor.authorDinçer İşoğlu, Sevilen_US
dc.date.accessioned2021-12-27T12:50:58Z-
dc.date.available2021-12-27T12:50:58Z-
dc.date.issued2021-10-28-
dc.identifier.urihttps://doi.org/10.1002/mabi.202100375-
dc.identifier.urihttps://hdl.handle.net/11147/11887-
dc.descriptionThis work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK), Project Number: 116R057. N.N.B. and G.T.U. were supported by TÜBİTAK 116R057.en_US
dc.description.abstractHere, a targeted, dual-pH responsive, and stable micelle nanocarrier is designed, which specifically selects an HER2 receptor on breast cancer cells. Intracellularly degradable and stabilized micelles are prepared by core cross-linking via reversible addition-fragmentation chain-transfer (RAFT) polymerization with an acid-sensitive cross-linker followed by the conjugation of maleimide-doxorubicin to the pyridyl disulfide-modified micelles. Multifunctional nanocarriers are obtained by coupling HER2-specific peptide. Formation of micelles, addition of peptide and doxorubicin (DOX) are confirmed structurally by spectroscopical techniques. Size and morphological characterization are performed by Zetasizer and transmission electron microscope (TEM). For the physicochemical verification of the synergistic acid-triggered degradation induced by acetal and hydrazone bond degradation, Infrared spectroscopy and particle size measurements are used. Drug release studies show that DOX release is accelerated at acidic pH. DOX-conjugated HER2-specific peptide-carrying nanocarriers significantly enhance cytotoxicity toward SKBR-3 cells. More importantly, no selectivity toward MCF-10A cells is observed compared to HER2(+) SKBR-3 cells. Formulations cause apoptosis depending on Bax and Caspase-3 and cell cycle arrest in G2 phase. This study shows a novel system for HER2-targeted therapy of breast cancer with a multifunctional nanocarrier, which has higher stability, dual pH-sensitivity, selectivity, and it can be an efficient way of targeted anticancer drug delivery.en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relationMeme Kanseri Hedefli, Kararlılığı Arttırılmış, İki Bölgeden pH’ya Duyarlı, İlaç Konjuge, Çok Fonksiyonlu Misel Nanotaşıyıcıların Geliştirilmesi ve in vitro Etkinliklerinin Belirlenmesien_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMicelle nanocarriersen_US
dc.subjectBreast canceren_US
dc.subjectCross-linked micellesen_US
dc.subjectRAFT polymerizationen_US
dc.subjectHER2 targetingen_US
dc.titleHER2-targeted, degradable core cross-linked micelles for specific and dual pH-sensitive DOX releaseen_US
dc.typeArticleen_US
dc.authorid0000-0002-1056-4673en_US
dc.institutionauthorUlu, Gizem Tuğçeen_US
dc.institutionauthorBaran, Yusufen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000715877100001en_US
dc.identifier.scopus2-s2.0-85118678301en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/mabi.202100375-
dc.identifier.pmid34708562en_US
dc.contributor.affiliationAbdullah Gül Üniversitesien_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliationYıldız Teknik Üniversitesien_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliationAbdullah Gül Üniversitesien_US
dc.relation.issn1616-5187en_US
dc.relation.grantno116R057en_US
local.message.claim2022-12-08T16:31:44.588+0300|||rp00306|||submit_approve|||dc_contributor_author|||None*
dc.identifier.wosqualityQ1-
item.grantfulltextembargo_20250101-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.dept01.01. Units Affiliated to the Rectorate-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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