Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12059
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dc.contributor.authorTomak, Ayselen_US
dc.contributor.authorÇeşmeli, Selinen_US
dc.contributor.authorHanoğlu, Berçem Dilanen_US
dc.contributor.authorWinkler, Daviden_US
dc.contributor.authorÖksel Karakuş, Ceyda-
dc.date.accessioned2022-04-20T09:03:59Z-
dc.date.available2022-04-20T09:03:59Z-
dc.date.issued2021-
dc.identifier.urihttps://hdl.handle.net/11147/12059-
dc.identifier.urihttps://doi.org/10.1080/17435390.2022.2025467-
dc.description.abstractThe surfaces of pristine nanoparticles become rapidly coated by proteins in biological fluids, forming the so-called protein corona. The corona modifies key physicochemical characteristics of nanoparticle surfaces that modulate its biological and pharmacokinetic activity, biodistribution, and safety. In the two decades since the protein corona was identified, the importance of nano particles surface properties in regulating biological responses have been recognized. However, there is still a lack of clarity about the relationships between physiological conditions and cor ona composition over time, and how this controls biological activities/interactions. Here we review recent progress in characterizing the structure and composition of protein corona as a function of biological fluid and time. We summarize the influence of nanoparticle characteristics on protein corona composition and discuss the relevance of protein corona to the biological activity and fate of nanoparticles. The aim is to provide a critical summary of the key factors that affect protein corona formation (e.g. characteristics of nanoparticles and biological environ ment) and how the corona modulates biological activity, cellular uptake, biodistribution, and drug delivery. In addition to a discussion on the importance of the characterization of protein corona adsorbed on nanoparticle surfaces under conditions that mimic relevant physiological environment, we discuss the unresolved technical issues related to the characterization of nano particle-protein corona complexes during their journey in the body. Lastly, the paper offers a perspective on how the existing nanomaterial toxicity data obtained from in vitro studies should be reconsidered in the light of the presence of a protein corona, and how recent advances in fields, such as proteomics and machine learning can be integrated into the quantitative analysis of protein corona components.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relationSafer-by-design Strategies for Bio-Nanomaterials (SAFEbionano)en_US
dc.relation.ispartofNanotoxicologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectProtein coronaen_US
dc.subjectNanoparticlesen_US
dc.subjectProtein corona characterizationen_US
dc.subjectBiological activityen_US
dc.subjectNanomaterialsen_US
dc.titleNanoparticle-protein corona complex: understanding multiple interactions between environmental factors, corona formation, and biological activityen_US
dc.typeArticleen_US
dc.authorid0000-0003-2544-5201en_US
dc.authorid0000-0002-3342-8690en_US
dc.institutionauthorTomak, Ayselen_US
dc.institutionauthorÇeşmeli, Selinen_US
dc.institutionauthorÖksel Karakuş, Ceyda-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000745341000001en_US
dc.identifier.scopus2-s2.0-85123445329en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1080/17435390.2022.2025467-
dc.identifier.pmid35061957-
dc.identifier.urlhttps://doi.org/10.1080/17435390.2022.2025467-
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliationArdahan Üniversitesien_US
dc.contributor.affiliationUniversity of Nottinghamen_US
dc.relation.issn1743-5390en_US
dc.description.volume15en_US
dc.description.issue10en_US
dc.description.startpage1331en_US
dc.description.endpage1357en_US
dc.relation.grantno118C229en_US
local.message.claim2022-06-08T11:09:18.483+0300|||rp00482|||submit_approve|||dc_contributor_author|||None*
dc.identifier.wosqualityttpTop10%en_US
item.grantfulltextembargo_20250101-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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