Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12178
Title: A Perspective on polythiophenes as conformation dependent optical reporters for label-free bioanalytics
Authors: Sinsinbar, Gaurav
Palaniappan, Alagappan
Yıldız, Ümit Hakan
Liedberg, Bo
Nanyang Technological University
Nanyang Technological University
Izmir Institute of Technology
Nanyang Technological University
Keywords: Bacterial pathogens
Bioimaging
Conjugated polyelectrolyte
Issue Date: 25-Mar-2022
Publisher: American Chemical Society
Abstract: Poly(3-alkylthiophene) (PT)-based conjugated polyelectrolytes (CPEs) constitute an important class of responsive polymers with excellent optical properties. The electrostatic interactions between PTs and target analytes trigger complexation and concomitant conformational changes of the PT backbones that produce distinct optical responses. These conformation-induced optical responses of the PTs enable them to be utilized as reporters for detection of various analytes by employing simple UV-vis spectrophotometry or the naked eye. Numerous PTs with unique pendant groups have been synthesized to tailor their interactions with analytes such as nucleotides, ions, surfactants, proteins, and bacterial and viral pathogens. In this perspective, we discuss PT-target analyte complexation for bioanalytical applications and highlight recent advancements in point-of-care and field deployable assays. Subsequently, we highlight a few areas of critical importance for future applications of PTs as reporters, including (i) design and synthesis of specific PTs to advance the understanding of the mechanisms of interaction with target analytes, (ii) using arrays of PTs and linear discriminant analysis for selective and specific detection of target analytes, (iii) translation of conventional homogeneous solution-based assays into heterogeneous membrane-based assay formats, and finally (iv) the potential of using PT as an alternative to conjugated polymer nanoparticles and dots in bioimaging.
URI: https://doi.org/10.1021/acssensors.1c02476
https://hdl.handle.net/11147/12178
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
12178.pdfArticle13.35 MBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

5
checked on Feb 17, 2024

WEB OF SCIENCETM
Citations

5
checked on Feb 17, 2024

Page view(s)

19,894
checked on Feb 23, 2024

Download(s)

1,102
checked on Feb 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.