Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12179
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dc.contributor.authorTatlıdil, Enginen_US
dc.contributor.authorGürbüz, Nergizen_US
dc.contributor.authorDoğanlar, Samien_US
dc.contributor.authorFrary, Anneen_US
dc.date.accessioned2022-07-19T07:48:15Z-
dc.date.available2022-07-19T07:48:15Z-
dc.date.issued2022-04-
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103194-
dc.identifier.urihttps://hdl.handle.net/11147/12179-
dc.description.abstractThe eggplant glycoalkaloids solasonine and solamargine are efficient biomacromolecules against skin diseases but are water-insoluble which results in inefficient treatment due to inadequate transdermal delivery. To address this problem, several liposomal formulations were prepared and evaluated for parameters including lecithin type, hydration temperature, and pH. The optimal formula with high physical and chemical stability included the lecithin Phospholipon 80H hydrated with 10 mM NaCl (pH 5.5). Solasonine - solamargine loaded liposomes were tested for their physical and chemical stability and drug leakage over a three-month period. Furthermore, the drug release profile of the loaded liposomes was evaluated with different release media. The glycoalkaloids and their liposomal formulations were assessed for their biological activity in culture using HaCaT and SCC-25 cell lines. This work resulted in a biologically effective liposomal formulation that was stable (size <220 nm, PDI [removed]80%) for at least three months.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBiomacromoleculesen_US
dc.subjectGenus solanumen_US
dc.subjectLiposomesen_US
dc.titleDevelopment of liposomal formulations of the eggplant glycoalkaloids solasonine and solamargineen_US
dc.typeArticleen_US
dc.authorid0000-0002-1161-7917en_US
dc.authorid0000-0003-1100-910X-
dc.authorid0000-0002-5712-0826-
dc.authorid0000-0002-8973-0100-
dc.institutionauthorTatlıdil, Enginen_US
dc.institutionauthorGürbüz, Nergizen_US
dc.institutionauthorDoğanlar, Samien_US
dc.institutionauthorFrary, Anneen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000792902200001en_US
dc.identifier.scopus2-s2.0-85125661255en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jddst.2022.103194-
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn17732247en_US
dc.description.volume70en_US
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.grantfulltextembargo_20250701-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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