Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12215
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYalçın, Damlaen_US
dc.contributor.authorTop, Aybenen_US
dc.date.accessioned2022-07-28T12:02:35Z-
dc.date.available2022-07-28T12:02:35Z-
dc.date.issued2022-
dc.identifier.urihttps://doi.org/10.1007/s13726-022-01058-4-
dc.identifier.urihttps://hdl.handle.net/11147/12215-
dc.description.abstractMerino wool obtained from the Karacabey region of Turkey was solubilized using peracetic acid oxidation. The wool and extracted wool proteins (keratose) were characterized using SEM, XRD, TGA, and FTIR analyses. SDS-PAGE result of the keratose indicated diffusive bands were populated between ~ 40 and ~ 55 kDa, corresponding to low-sulfur content α-keratose proteins. Chemically crosslinked hydrogels were prepared using the keratose and tetrakis(hydroxymethyl) phosphonium chloride (THPC). Storage moduli of the hydrogels prepared at 1:1, 1:2, and 1:4 keratose to THPC reactive group ratios were measured as 63 ± 22, 291 ± 21, and 804 ± 53 Pa, respectively. Crosslinking degrees of the hydrogels also affected the secondary structures of the keratose films obtained from the drying of the hydrogels. The hydrogel with the highest crosslinking density (1:4 gel) exhibited the lowest swelling ratio, whereas the one with the lowest crosslinking density (1:1 gel) disintegrated in deionized water within less than 6 h. CCK-8 tests using L929 mouse fibroblast cells showed that all the hydrogels promoted cell proliferation. These results suggest THPC crosslinked hydrogels prepared at the millimolar THPC concentrations are biocompatible scaffolds, which can be utilized in drug delivery and tissue engineering applications. Graphical abstract: [Figure not available: see fulltext.]en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofIranian Polymer Journal (English Edition)en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBiopolymersen_US
dc.subjectChemical crosslinkingen_US
dc.subjectHydrogelen_US
dc.titleNovel biopolymer-based hydrogels obtained through crosslinking of keratose proteins using tetrakis(hydroxymethyl) phosphonium chlorideen_US
dc.typeArticleen_US
dc.authorid0000-0002-0944-0585en_US
dc.authorid0000-0003-0554-2506en_US
dc.institutionauthorYalçın, Damlaen_US
dc.institutionauthorTop, Aybenen_US
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.wosWOS:000797277900001en_US
dc.identifier.scopus2-s2.0-85130263907en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s13726-022-01058-4-
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn1026-1265en_US
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextembargo_20250701-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
s13726-022-01058-4.pdf
  Until 2025-07-01
Article2.77 MBAdobe PDFView/Open    Request a copy
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

3
checked on Feb 16, 2024

WEB OF SCIENCETM
Citations

2
checked on Jan 27, 2024

Page view(s)

6,096
checked on Feb 23, 2024

Download(s)

2
checked on Feb 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.