Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12243
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dc.contributor.authorAkgün, Oğuzhanen_US
dc.contributor.authorAkgün, Halimeen_US
dc.contributor.authorŞahin, Çağatayen_US
dc.contributor.authorÇelikler, Serapen_US
dc.contributor.authorArı, Ferdaen_US
dc.date.accessioned2022-08-03T07:15:00Z-
dc.date.available2022-08-03T07:15:00Z-
dc.date.issued2022-
dc.identifier.issn1516-8913-
dc.identifier.urihttps://doi.org/10.1590/1678-4324-2022210065-
dc.identifier.urihttps://hdl.handle.net/11147/12243-
dc.description.abstractAngelica sylvestris and Delphinium staphisagria are medicinal and aromatic herbs with a long history in medicine and food industry. In this study, we have investigated anti-cancer activity of Angelica sylvestris and Delphinium staphisagria extracts on various cell lines of lung (A549), breast (MCF-7), colon (HT-29), and cervix (HeLa) origin. Also, cytotoxicity was tested on human healthy bronchial epithelial (BEAS-2B) cells. In vitro experiments showed that plant extracts suppressed cell growth and proliferation at low concentrations by reducing cell viability on cancer cells in a time and concentration-dependent manner. It was observed that Angelica sylvestris was more effective in HT-29 and HeLa cells and Delphinium staphisagria in A549 and MCF-7 cells by suppressing cell proliferation and increasing cell death. Cell death mode (apoptosis/necrosis) was investigated via fluorescent imaging, caspase-cleaved cytokeratin 18, activated caspase-3, and cleaved-PARP (poly (ADP-ribose) polymerase). In order to evaluate the cell death mode by plant extracts apoptotic markers were investigated by fluorescence staining. Delphinium staphisagria extract (50-200 μg/mL) caused a decrease in cell density in A549 and MCF-7 cells compared to untreated controls. A similar situation was observed in HT-29 and HeLa cell lines when treated with ASE. As a result, Delphinium staphisagria extracts induced apoptosis in A549 and MCF-7, while Angelica sylvestris extracts induced apoptosis in HT-29 and HeLa cancer cellsen_US
dc.language.isoenen_US
dc.publisherInstituto de Tecnologia do Paranaen_US
dc.relation.ispartofBrazilian Archives of Biology and Technologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngelica sylvestrisen_US
dc.subjectApoptosisen_US
dc.subjectCancer cellsen_US
dc.subjectDelphinium staphisagriaen_US
dc.titleAngelica Sylvestris and Delphinium Staphisagria Extracts Induces Antiproliferation Through Caspase-Mediated Apoptosis on Human Cancer Cellsen_US
dc.typeArticleen_US
dc.authorid0000-0001-5742-4902en_US
dc.institutionauthorŞahin, Çağatayen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000796649200001en_US
dc.identifier.scopus2-s2.0-85129267881en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/1678-4324-2022210065-
dc.contributor.affiliationUludağ Üniversitesien_US
dc.contributor.affiliationUludağ Üniversitesien_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationUludağ Üniversitesien_US
dc.contributor.affiliationUludağ Üniversitesien_US
dc.relation.issn1516-8913en_US
dc.description.volume65en_US
dc.identifier.wosqualityQ4-
dc.identifier.scopusqualityQ2-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01. Izmir Institute of Technology-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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