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https://hdl.handle.net/11147/12243
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akgün, Oğuzhan | en_US |
dc.contributor.author | Akgün, Halime | en_US |
dc.contributor.author | Şahin, Çağatay | en_US |
dc.contributor.author | Çelikler, Serap | en_US |
dc.contributor.author | Arı, Ferda | en_US |
dc.date.accessioned | 2022-08-03T07:15:00Z | - |
dc.date.available | 2022-08-03T07:15:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1516-8913 | - |
dc.identifier.uri | https://doi.org/10.1590/1678-4324-2022210065 | - |
dc.identifier.uri | https://hdl.handle.net/11147/12243 | - |
dc.description.abstract | Angelica sylvestris and Delphinium staphisagria are medicinal and aromatic herbs with a long history in medicine and food industry. In this study, we have investigated anti-cancer activity of Angelica sylvestris and Delphinium staphisagria extracts on various cell lines of lung (A549), breast (MCF-7), colon (HT-29), and cervix (HeLa) origin. Also, cytotoxicity was tested on human healthy bronchial epithelial (BEAS-2B) cells. In vitro experiments showed that plant extracts suppressed cell growth and proliferation at low concentrations by reducing cell viability on cancer cells in a time and concentration-dependent manner. It was observed that Angelica sylvestris was more effective in HT-29 and HeLa cells and Delphinium staphisagria in A549 and MCF-7 cells by suppressing cell proliferation and increasing cell death. Cell death mode (apoptosis/necrosis) was investigated via fluorescent imaging, caspase-cleaved cytokeratin 18, activated caspase-3, and cleaved-PARP (poly (ADP-ribose) polymerase). In order to evaluate the cell death mode by plant extracts apoptotic markers were investigated by fluorescence staining. Delphinium staphisagria extract (50-200 μg/mL) caused a decrease in cell density in A549 and MCF-7 cells compared to untreated controls. A similar situation was observed in HT-29 and HeLa cell lines when treated with ASE. As a result, Delphinium staphisagria extracts induced apoptosis in A549 and MCF-7, while Angelica sylvestris extracts induced apoptosis in HT-29 and HeLa cancer cells | en_US |
dc.language.iso | en | en_US |
dc.publisher | Instituto de Tecnologia do Parana | en_US |
dc.relation.ispartof | Brazilian Archives of Biology and Technology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Angelica sylvestris | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cancer cells | en_US |
dc.subject | Delphinium staphisagria | en_US |
dc.title | Angelica Sylvestris and Delphinium Staphisagria Extracts Induces Antiproliferation Through Caspase-Mediated Apoptosis on Human Cancer Cells | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0001-5742-4902 | en_US |
dc.institutionauthor | Şahin, Çağatay | en_US |
dc.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
dc.identifier.wos | WOS:000796649200001 | en_US |
dc.identifier.scopus | 2-s2.0-85129267881 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1590/1678-4324-2022210065 | - |
dc.contributor.affiliation | Uludağ Üniversitesi | en_US |
dc.contributor.affiliation | Uludağ Üniversitesi | en_US |
dc.contributor.affiliation | Izmir Institute of Technology | en_US |
dc.contributor.affiliation | Uludağ Üniversitesi | en_US |
dc.contributor.affiliation | Uludağ Üniversitesi | en_US |
dc.relation.issn | 1516-8913 | en_US |
dc.description.volume | 65 | en_US |
dc.identifier.wosquality | Q4 | - |
dc.identifier.scopusquality | Q2 | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | 01. Izmir Institute of Technology | - |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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