Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12294
Title: The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity
Authors: Rasmi, Yousef
Heidari, Nadia
Kübra Kırboğa, Kevser
Hatamkhani, Shima
Tekin, Burcu
Alipour, Shahryar
Naderi, Roya
Farnamian, Yeghaneh
Akça, İlknur
Urmia University of Medical Sciences
Golestan University of Medical Sciences
Süleyman Demirel Üniversitesi
Urmia University of Medical Sciences
01. Izmir Institute of Technology
Urmia University of Medical Sciences
Urmia University of Medical Sciences
Urmia University of Medical Sciences
Mersin Üniversitesi
Keywords: COVID-19
Neopterin
Prognosis
SARS CoV-2
Issue Date: Jun-2022
Publisher: Elsevier
Abstract: Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
URI: https://doi.org/10.1016/j.clinbiochem.2022.03.002
https://hdl.handle.net/11147/12294
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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