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https://hdl.handle.net/11147/12407
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hamid, Syed Muhammad | en_US |
dc.contributor.author | Akgül, Bünyamin | tr |
dc.date.accessioned | 2022-08-24T11:43:17Z | - |
dc.date.available | 2022-08-24T11:43:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1300-0152 | - |
dc.identifier.uri | http://dx.doi.org/10.55730/1300-0152.2610 | - |
dc.identifier.uri | https://hdl.handle.net/11147/12407 | - |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/532172 | - |
dc.description.abstract | Transfer ribonucleic acids (tRNAs) serve not only as amino acid carriers during translation but also as a template for the biogenesis of short fragments that can regulate gene expression. Despite recent progress in the function of tRNA-derived fragments (tRFs), their intracellular localization, protein partners, and role in regulating translation are not well understood. We used synthetic tRFs to investigate their localization and function in Drosophila S2 cells. Under our experimental setting, all synthetic tRFs tested were localized at distinct sites within the cytoplasm in a similar manner in Drosophila S2 cells. Cytoplasmically-localized tRFs were positioned in close proximity to GW182 and XRN1 proteins. Functionally, tRFs, which slightly suppressed proliferation in S2 cells, inhibited translation without any major shift in the polysome profile. These results suggest that 5???-tRFs are cytoplasmically-localized and regulate gene expression through inhibition of translation in Drosophila. | en_US |
dc.language.iso | en | en_US |
dc.publisher | TÜBİTAK - Türkiye Bilimsel ve Teknolojik Araştırma Kurumu | en_US |
dc.relation | TRNA'lardan Kökenlenen Küçük RNA Fragmanlarının Etkileştiği Komplekslerin Tanımlanması ve Gelişim Üzerine Etkilerinin Araştırılması | tr |
dc.relation.ispartof | Turkish Journal of Biology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | TRF | en_US |
dc.subject | Transfer ribonucleic acids | en_US |
dc.subject | Drosophila | en_US |
dc.subject | tRNA fragments | en_US |
dc.title | Cytoplasmically localized tRNA-derived fragments inhibit translation in Drosophila S2 cells | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0001-9877-9689 | en_US |
dc.institutionauthor | Akgül, Bünyamin | tr |
dc.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
dc.identifier.wos | WOS:000815169200003 | en_US |
dc.identifier.scopus | 2-s2.0-85134582294 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr |
dc.identifier.doi | 10.55730/1300-0152.2610 | - |
dc.contributor.affiliation | University of California, Los Angeles | en_US |
dc.contributor.affiliation | Izmir Institute of Technology | en_US |
dc.relation.issn | 1300-0152 | en_US |
dc.description.volume | 46 | en_US |
dc.description.issue | 3 | en_US |
dc.description.startpage | 216 | en_US |
dc.description.endpage | 226 | en_US |
dc.relation.grantno | 210T006 | en_US |
dc.identifier.trdizinid | 532172 | en_US |
dc.identifier.wosquality | Q3 | - |
dc.identifier.scopusquality | Q3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | 04.03. Department of Molecular Biology and Genetics | - |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Cytoplasmically localized tRNA.pdf | 4.46 MB | Adobe PDF | View/Open |
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