Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12407
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dc.contributor.authorHamid, Syed Muhammaden_US
dc.contributor.authorAkgül, Bünyamintr
dc.date.accessioned2022-08-24T11:43:17Z-
dc.date.available2022-08-24T11:43:17Z-
dc.date.issued2022-
dc.identifier.urihttp://dx.doi.org/10.55730/1300-0152.2610-
dc.identifier.urihttps://hdl.handle.net/11147/12407-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/532172-
dc.description.abstractTransfer ribonucleic acids (tRNAs) serve not only as amino acid carriers during translation but also as a template for the biogenesis of short fragments that can regulate gene expression. Despite recent progress in the function of tRNA-derived fragments (tRFs), their intracellular localization, protein partners, and role in regulating translation are not well understood. We used synthetic tRFs to investigate their localization and function in Drosophila S2 cells. Under our experimental setting, all synthetic tRFs tested were localized at distinct sites within the cytoplasm in a similar manner in Drosophila S2 cells. Cytoplasmically-localized tRFs were positioned in close proximity to GW182 and XRN1 proteins. Functionally, tRFs, which slightly suppressed proliferation in S2 cells, inhibited translation without any major shift in the polysome profile. These results suggest that 5???-tRFs are cytoplasmically-localized and regulate gene expression through inhibition of translation in Drosophila.en_US
dc.language.isoenen_US
dc.publisherTÜBİTAK - Türkiye Bilimsel ve Teknolojik Araştırma Kurumuen_US
dc.relationTRNA'lardan Kökenlenen Küçük RNA Fragmanlarının Etkileştiği Komplekslerin Tanımlanması ve Gelişim Üzerine Etkilerinin Araştırılmasıtr
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTRFen_US
dc.subjectTransfer ribonucleic acidsen_US
dc.subjectDrosophilaen_US
dc.subjecttRNA fragmentsen_US
dc.titleCytoplasmically localized tRNA-derived fragments inhibit translation in Drosophila S2 cellsen_US
dc.typeArticleen_US
dc.authorid0000-0001-9877-9689en_US
dc.institutionauthorAkgül, Bünyamintr
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000815169200003en_US
dc.identifier.scopus2-s2.0-85134582294en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr
dc.identifier.doi10.55730/1300-0152.2610-
dc.contributor.affiliationUniversity of California, Los Angelesen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn1300-0152en_US
dc.description.volume46en_US
dc.description.issue3en_US
dc.description.startpage216en_US
dc.description.endpage226en_US
dc.relation.grantno210T006en_US
dc.identifier.trdizinid532172en_US
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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