Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12441
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dc.contributor.authorKarakuzu, Betülen_US
dc.contributor.authorTarım, Ergün Alperayen_US
dc.contributor.authorÖksüz, Cemreen_US
dc.contributor.authorTekin, Hüseyin Cumhuren_US
dc.date.accessioned2022-09-20T11:51:33Z-
dc.date.available2022-09-20T11:51:33Z-
dc.date.issued2022-07-
dc.identifier.urihttps://doi.org/10.1021/acsomega.2c03354-
dc.identifier.urihttps://hdl.handle.net/11147/12441-
dc.description.abstractChronic kidney disease (CKD) is a high-cost disease that affects approximately one in ten people globally, progresses rapidly, results in kidney failure or dialysis, and triggers other diseases. Although clinically used serum creatinine tests are used to evaluate kidney functions, these tests are not suitable for frequent and regular control at-home settings that obstruct the regular monitoring of kidney functions, improving CKD management with early intervention. This study introduced a new electromechanical lab-on-a-chip platform for point-of-care detection of serum creatinine levels using colorimetric enzyme-linked immunosorbent assay (ELISA). The platform was composed of a chip containing microreservoirs, a stirring bar coated with creatinine-specific antibodies, and a phone to detect color generated via ELISA protocols to evaluate creatinine levels. An electromechanical system was used to move the stirring bar to different microreservoirs and stir it inside them to capture and detect serum creatinine in the sample. The presented platform allowed automated analysis of creatinine in ~50 min down to ~1 and ~2 mg/dL in phosphate-buffered saline (PBS) and fetal bovine serum (FBS), respectively. Phone camera measurements in hue, saturation, value (HSV) space showed sensitive analysis compared to a benchtop spectrophotometer that could allow low-cost analysis at point-of-care.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relationYonga Üstü Laboratuvar Platformunda Otomatize Elisa Protokolleri Kullanarak Kreatinin Kantitatif Analizien_US
dc.relation.ispartofACS Omegaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectELISAen_US
dc.subjectSerum creatinineen_US
dc.subjectBiopolymersen_US
dc.titleAn electromechanical lab-on-a-chip platform for colorimetric detection of serum creatinineen_US
dc.typeArticleen_US
dc.authorid0000-0001-6517-7251en_US
dc.authorid0000-0003-3455-3167en_US
dc.authorid0000-0002-9700-2656en_US
dc.authorid0000-0002-5758-5439en_US
dc.institutionauthorKarakuzu, Betülen_US
dc.institutionauthorTarım, Ergün Alperayen_US
dc.institutionauthorÖksüz, Cemreen_US
dc.institutionauthorTekin, Hüseyin Cumhuren_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000830488100001en_US
dc.identifier.scopus2-s2.0-85135560311en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1021/acsomega.2c03354-
dc.identifier.pmid35910133-
dc.relation.issn2470-1343en_US
dc.description.volume7en_US
dc.description.issue29en_US
dc.description.startpage25837en_US
dc.description.endpage25843en_US
dc.relation.grantno217S518en_US
dc.identifier.scopusqualityQ1-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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