Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12490
Title: Non-apoptotic cell death induction via sapogenin based supramolecular particles
Authors: Üner, Göklem
Bedir, Erdal
Serçinoğlu, Onur
Ballar Kırmızıbayrak, Petek
Keywords: Cell death
Supramolecular particles
Anticancer drug research
Sapogenins
Issue Date: Dec-2022
Publisher: Nature Publishing Group
Abstract: The discovery of novel chemotherapeutics that act through different mechanisms is critical for dealing with tumor heterogeneity and therapeutic resistance. We previously reported a saponin analog (AG-08) that induces non-canonical necrotic cell death and is auspicious for cancer therapy. Here, we describe that the key element in triggering this unique cell death mechanism of AG-08 is its ability to form supramolecular particles. These self-assembled particles are internalized via a different endocytosis pathway than those previously described. Microarray analysis suggested that AG-08 supramolecular structures affect several cell signaling pathways, including unfolded protein response, immune response, and oxidative stress. Finally, through investigation of its 18 analogs, we further determined the structural features required for the formation of particulate structures and the stimulation of the unprecedented cell death mechanism of AG-08. The unique results of AG-08 indicated that supramolecular assemblies of small molecules are promising for the field of anticancer drug development, although they have widely been accepted as nuisance in drug discovery studies.
URI: https://doi.org/10.1038/s41598-022-17977-4
https://hdl.handle.net/11147/12490
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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