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Title: Development of 3D cardiac models via magnetic manipulation for drug screening studies
Authors: Önbaş, Rabia
Arslan Yıldız, Ahu
Keywords: Contactless magnetic manipulation
Cardiac tissue engineering
Drug screening assays
Issue Date: 2022
Publisher: Mary Ann Liebert
Abstract: Drug discovery and development process comprise of preclinical and clinical phases that are very intensive, long, and expensive research phases. However, drug candidates can fail in clinical trials. Toxicity is the major reason that leads to about 30% of drug development failures. Recently, the withdrawal rate of drugs from the market was increased to 33.3%from5.1%due to cardiotoxicity. When the drug fails at phase I, the reasons are probably related to 2-dimensional (2D) cell culture studies that do not represent the real tissue physiology; therefore, they provide misdirected data about the efficacy and toxicity of drug.
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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