Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12550
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dc.contributor.authorKimna, Cerenen_US
dc.contributor.authorDeğer, Sibelen_US
dc.contributor.authorTamburacı, Sedefen_US
dc.contributor.authorTıhmınlıoğlu, Fundaen_US
dc.date.accessioned2022-10-21T11:42:08Z-
dc.date.available2022-10-21T11:42:08Z-
dc.date.issued2022-10-
dc.identifier.issn0021-8995-
dc.identifier.urihttps://doi.org/10.1002/app.52955-
dc.identifier.urihttps://hdl.handle.net/11147/12550-
dc.description.abstractAlthough nanofillers contribute to improved physical characteristics and biological functionalities of polymer-based biomaterials, their dispersion in polymer matrices is still a challenging issue in terms of obtaining consistency for the inherent properties. To tackle this problem, homogenization techniques are applied to disperse the nanofillers in such polymers, however, these methods can cause undesired changes especially in the rheological properties and the physical structure of the biopolymer matrices. Recently, as a novel homogenization technique, microfluidization has been used to homogenize polymer nanocomposites to minimize these limitations. In this study, two different nanocomposite structures as chitosan/montmorillonite (CS/MMT) and chitosan/polyhedral oligomeric silsesquioxane nanocages (CS/POSS) were homogenized with microfluidization and investigated in terms of physical alterations. Furthermore, the effect of microfluidizer technique on material characteristics was compared with conventional homogenization techniques, i.e., ultrasonic bath and sonication in terms of solution, nano – (e.g., hydrodynamic size, drug encapsulation) and macroscopic material characteristics (e.g., porosity, mechanical properties, swelling and thermal degradation). It was found that the microfluidizer homogenization improves the physical characteristics in both nano and macroscale materials: Nanospheres obtained from CS/MMT composites showed enhanced stability, uniform size distribution (<100 nm, PDI: [removed]50%) whereas 3D porous CS/POSS scaffolds showed improved structural uniformity (i.e., homogeneous and interconnected microstructure) and enhanced thermal and mechanical properties. The obtained results indicate that the microfluidizer homogenization ensures a successful nanofiller dispersion in polymer matrices, thereby improving the biomaterial characteristics impressively compared to the sonication methods.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relationKontrollü Antibiyotik Salımı Yapan Kitosan/Silika Bazlı Kompozit Doku İskelelerinin Geliştirilmesi Ve Sert Doku Mühendisliği İçin Kullanım Potansiyelinin Araştırılmasıen_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBiomaterialsen_US
dc.subjectMechanical propertiesen_US
dc.subjectPolysaccharidesen_US
dc.subjectPorous materialsen_US
dc.titleMicrofluidic-assisted preparation of nano and microscale chitosan based 3D composite materials: Comparison with conventional methodsen_US
dc.typeArticleen_US
dc.authorid0000-0003-2283-4295en_US
dc.authorid0000-0001-9916-2971en_US
dc.authorid0000-0003-3234-226Xen_US
dc.authorid0000-0002-3715-8253en_US
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.wosWOS:000834838300001en_US
dc.identifier.scopus2-s2.0-85135296677en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/app.52955-
dc.relation.issn0021-8995en_US
dc.description.volume139en_US
dc.description.issue40en_US
dc.relation.grantno116M096en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextembargo_20250101-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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