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Title: miR-aculous new avenues for cancer immunotherapy
Authors: Tang, William W.
Bauer, Kaylyn M.
Barba, Cindy
Ekiz, Hüseyin Atakan
O’Connell, Ryan M.
University of Utah
University of Utah
University of Utah
University of Utah
Keywords: Cancer cells
Cell death
Cancer immunity
Tumor microenvironment
Issue Date: Sep-2022
Publisher: Frontiers Media S.A.
Abstract: The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical standards leave many current and future patients without options. Non-coding RNAs, specifically microRNAs, have been explored in pre-clinical contexts with tremendous success. MicroRNAs play indispensable roles in programming the interactions between immune and cancer cells, many of which are current or potential immunotherapy targets. MicroRNAs mechanistically control a network of target genes that can alter immune and cancer cell biology. These insights provide us with opportunities and tools that may complement and improve immunotherapies. In this review, we discuss immune and cancer cell–derived miRNAs that regulate cancer immunity and examine miRNAs as an integral part of cancer diagnosis, classification, and therapy.
Description: This work is supported by the Nation Institutes of Health 1F30CA260977 (WT), T32 Al138945 (KB), and 1F31CA261096 (CB).
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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