Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12727
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dc.contributor.authorTarım, Ergün Alperaytr
dc.contributor.authorÖksüz, Cemretr
dc.contributor.authorKarakuzu, Betültr
dc.contributor.authorAppak, Özgürtr
dc.contributor.authorSayıner, Ayça Arzutr
dc.contributor.authorTekin, Hüseyin Cumhurtr
dc.date.accessioned2023-01-05T08:21:50Z-
dc.date.available2023-01-05T08:21:50Z-
dc.date.issued2023-03-
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2022.124190-
dc.identifier.urihttps://hdl.handle.net/11147/12727-
dc.description.abstractRapid point-of-care tests for infectious diseases are essential, especially in pandemic conditions. We have developed a point-of-care electromechanical device to detect SARS-CoV-2 viral RNA using the reverse-transcription loop-mediated isothermal amplification (RT-LAMP) principle. The developed device can detect SARS-CoV-2 viral RNA down to 103 copies/mL and from a low amount of sample volumes (2 μL) in less than an hour of standalone operation without the need for professional labor and equipment. Integrated Peltier elements in the device keep the sample at a constant temperature, and an integrated camera allows automated monitoring of LAMP reaction in a stirring sample by using colorimetric analysis of unfocused sample images in the hue/saturation/value color space. This palm-fitting, portable and low-cost device does not require a fully focused sample image for analysis, and the operation could be stopped automatically through image analysis when the positive test results are obtained. Hence, viral infections can be detected with the portable device produced without the need for long, expensive, and labor-intensive tests and equipment, which can make the viral tests disseminated at the point-of-care.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relationYonga Üstü Laboratuvar Platformu ile Viral RNA’nın Otomatik Algılanmasıtr
dc.relation.ispartofTalantaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorimetric detectionen_US
dc.subjectSARS CoV-2en_US
dc.subjectElectromechanical systemsen_US
dc.titleElectromechanical RT-LAMP device for portable SARS-CoV-2 detectionen_US
dc.typeArticleen_US
dc.authorid0000-0003-3455-3167en_US
dc.authorid0000-0002-9700-2656en_US
dc.authorid0000-0001-6517-7251en_US
dc.authorid0000-0002-5758-5439en_US
dc.institutionauthorTarım, Ergün Alperaytr
dc.institutionauthorÖksüz, Cemretr
dc.institutionauthorKarakuzu, Betültr
dc.institutionauthorTekin, Hüseyin Cumhurtr
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:001003492200009en_US
dc.identifier.scopus2-s2.0-85143794800en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarıtr
dc.identifier.doi10.1016/j.talanta.2022.124190-
dc.identifier.pmid36521325-
dc.relation.issn0039-9140en_US
dc.description.volume254en_US
dc.relation.grantno2020IYTE0042en_US
dc.identifier.scopusqualityQ1-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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