Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13280
Title: Microfluidic-based technologies for diagnosis, prevention, and treatment of COVID-19: recent advances and future directions
Authors: Tarım, Ergün Alperay
Anıl İnevi, Müge
Özkan, İlayda
Keçili, Seren
Bilgi, Eyüp
Başlar, Muhammet Semih
Özçivici, Engin
Öksel Karakuş, Ceyda
Tekin, Hüseyin Cumhur
Keywords: COVID-19 detection
Vaccine
Drug development
Microfluidics
Organ-on-chip
Drug-Delivery
Rapid Detection
High-Throughput
Messenger-Rna
Gene Delivery
Sars-Cov-2
Point
Protein
Therapeutics
Fluorescence
Issue Date: 2023
Publisher: Springer
Abstract: The COVID-19 pandemic has posed significant challenges to existing healthcare systems around the world. The urgent need for the development of diagnostic and therapeutic strategies for COVID-19 has boomed the demand for new technologies that can improve current healthcare approaches, moving towards more advanced, digitalized, personalized, and patient-oriented systems. Microfluidic-based technologies involve the miniaturization of large-scale devices and laboratory-based procedures, enabling complex chemical and biological operations that are conventionally performed at the macro-scale to be carried out on the microscale or less. The advantages microfluidic systems offer such as rapid, low-cost, accurate, and on-site solutions make these tools extremely useful and effective in the fight against COVID-19. In particular, microfluidic-assisted systems are of great interest in different COVID-19-related domains, varying from direct and indirect detection of COVID-19 infections to drug and vaccine discovery and their targeted delivery. Here, we review recent advances in the use of microfluidic platforms to diagnose, treat or prevent COVID-19. We start by summarizing recent microfluidic-based diagnostic solutions applicable to COVID-19. We then highlight the key roles microfluidics play in developing COVID-19 vaccines and testing how vaccine candidates perform, with a focus on RNA-delivery technologies and nano-carriers. Next, microfluidic-based efforts devoted to assessing the efficacy of potential COVID-19 drugs, either repurposed or new, and their targeted delivery to infected sites are summarized. We conclude by providing future perspectives and research directions that are critical to effectively prevent or respond to future pandemics.
URI: https://doi.org/10.1007/s10544-023-00649-z
https://hdl.handle.net/11147/13280
ISSN: 1387-2176
1572-8781
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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