Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13299
Title: Short Lecture Novel neuroprotective metabolites produced via biotransformation of cyclocephagenol by Alternaria eureka 1E1BL1
Authors: Küçüksolak, Melis
Üner, Göklem
Ballar Kırmızıbayrak, Petek
Bedir, Erdal
Issue Date: 2022
Publisher: Georg Thieme Verlag
Abstract: Neurodegeneration refers to the loss of structure/function of neurons leading to neurological diseases including Alzheimerʼs and Parkinsonʼs. The discovery of novel therapeutics against neurodegenerative diseases has been an area of intense research as neurodegenerative diseases are a huge burden on society and the economy [1]. Numerous studies reported that natural products have the potential to prevent and treat neurodegeneration. Among these studies, the neuroprotective activities of cycloartane-type saponins are noteworthy [2], [3]. In our preliminary studies, the neuroprotective activity of cyclocephagenol, an aglycone of cyclocephaloside I from Astragalus microcephalus [4], was screened for H2O2-induced injury in SH-SY5Y cells. Based on the promising bioactivity of cyclocephagenol, the aims of this study were: i) to perform microbial transformation studies on cyclocephagenol using Alternaria eureka followed by isolation and structural characterization of the metabolites; ii) to investigate neuroprotective activities of the metabolites; iii) to understand structure-activity relationships towards neuroprotection.
URI: https://doi.org/10.1055/s-0042-1758940
https://hdl.handle.net/11147/13299
ISSN: 0032-0943
1439-0221
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

Page view(s)

18
checked on Feb 26, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.