Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13309
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dc.contributor.authorAlessio, Nicola-
dc.contributor.authorAcar, Mustafa Burak-
dc.contributor.authorSquillaro, Tiziana-
dc.contributor.authorAprile, Domenico-
dc.contributor.authorAyaz Güner, Şerife-
dc.contributor.authorDi Bernardo, Giovanni-
dc.contributor.authorÖzcan, Servet-
dc.date.accessioned2023-04-19T12:36:45Z-
dc.date.available2023-04-19T12:36:45Z-
dc.date.issued2023-
dc.identifier.issn0960-7722-
dc.identifier.issn1365-2184-
dc.identifier.urihttps://doi.org/10.1111/cpr.13401-
dc.identifier.urihttps://hdl.handle.net/11147/13309-
dc.description.abstractGenotoxic injuries converge on senescence-executive program that promotes production of a senescence-specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered in a few cells, can spread to many other cells and produce either beneficial or negative consequences for health. We analysed the SASP of quiescent mesenchymal stromal cells (MSCs) following stress induced premature senescence (SIPS) by ionizing radiation exposure. We performed a proteome analysis of SASP content obtained from early and late senescent cells. The bioinformatics studies evidenced that early and late SASPs, besides some common ontologies and signalling pathways, contain specific factors. In spite of these differences, we evidenced that SASPs can block in vitro proliferation of cancer cells and promote senescence/apoptosis. It is possible to imagine that SASP always contains core components that have an anti-tumour activity, the progression from early to late senescence enriches the SASP of factors that may promote SASP tumorigenic activity only by interacting and instructing cells of the immune system. Our results on Caco-2 cancer cells incubated with late SASP in presence of peripheral white blood cells strongly support this hypothesis. We evidenced that quiescent MSCs following SIPS produced SASP that, while progressively changed its composition, preserved the capacity to block cancer growth by inducing senescence and/or apoptosis only in an autonomous manner.en_US
dc.description.sponsorshipRegione Campania, Grant/Award Number: B21C17000030007en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Proliferationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSASPen_US
dc.subjectCancer cellsen_US
dc.subjectSIPSen_US
dc.subjectCellular senescenceen_US
dc.titleProgression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour propertiesen_US
dc.typeArticleen_US
dc.authorid0000-0002-1052-0961-
dc.institutionauthorAyaz Güner, Şerife-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000955121900001en_US
dc.identifier.scopus2-s2.0-85150869783en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/cpr.13401-
dc.identifier.pmid36949664en_US
dc.authorscopusid30367477800-
dc.authorscopusid57006292300-
dc.authorscopusid16022881200-
dc.authorscopusid57210577742-
dc.authorscopusid33567596300-
dc.authorscopusid56962760700-
dc.authorscopusid35548562200-
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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