Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13311
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dc.contributor.authorCan, İsmail-
dc.contributor.authorSakemura, Reona Leo-
dc.contributor.authorManriquez-Roman, Claudia-
dc.contributor.authorSirpilla, Olivia-
dc.contributor.authorStewart, Carli M.-
dc.contributor.authorYun, Kun-
dc.contributor.authorCox, Michelle J.-
dc.contributor.authorEkiz, Atakantr
dc.date.accessioned2023-04-19T12:36:45Z-
dc.date.available2023-04-19T12:36:45Z-
dc.date.issued2022-
dc.identifier.issn0006-4971-
dc.identifier.issn1528-0020-
dc.identifier.urihttps://doi.org/10.1182/blood-2022-163446-
dc.identifier.urihttps://hdl.handle.net/11147/13311-
dc.description.abstractCD19-directed chimeric antigen receptor (CART19) cells have emerged as a potentially curative immunotherapy in a subset of patients with hematological malignancies. While initial responses are impressive, the majority of responsive patients relapse within a year. Recent studies suggest that CART cells are susceptible to states of dysfunction. We aimed to study the development of T cell senescence in CART cells using similar constructs to the FDA-approved therapies, CART19-BBζ and CART19-28ζ, to determine the impact of co-stimulatory domains on CART cell senescence. We developed an in vitro model for repeated CART cell activation followed by rest to study the development of senescence and its impact on effector T cell functions. We examined CART cell immunophenotype, cell cycle regulators, and transcriptomic profile on days 0 (T cell), D8 (standard CART cell), 15 (after one activation cycle) and 22 (after two activation cycles).en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Hematologyen_US
dc.relation.ispartofBlooden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDifferential Susceptibility To Senescence in Cart Cells Based on Co-Stimulatory Signalingen_US
dc.typeConference Objecten_US
dc.institutionauthorEkiz, Atakan-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume140en_US
dc.identifier.startpage8600en_US
dc.identifier.endpage8601en_US
dc.identifier.wosWOS:000893230301293en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1182/blood-2022-163446-
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeConference Object-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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