Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13602
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dc.contributor.authorAldemir Dikici, Betül-
dc.contributor.authorChen, Min-Chia-
dc.contributor.authorDikici, Serkan-
dc.contributor.authorChiu, Hsien-Chung-
dc.contributor.authorClaeyssens, Frederik-
dc.date.accessioned2023-07-27T19:49:58Z-
dc.date.available2023-07-27T19:49:58Z-
dc.date.issued2023-06-
dc.identifier.issn1944-8244-
dc.identifier.issn1944-8252-
dc.identifier.urihttps://doi.org/10.1021/acsami.3c04362-
dc.identifier.urihttps://hdl.handle.net/11147/13602-
dc.description.abstractGlobally, one of the most common tissue transplantationproceduresis bone grafting. Lately, we have reported the development of polymerizedhigh internal phase emulsions (PolyHIPEs) made of photocurable polycaprolactone(4PCLMA) and shown their potential to be used as bone tissue engineeringscaffolds in vitro. However, it is essential to evaluatethe in vivo performance of these scaffolds to investigatetheir potential in a clinically more relevant manner. Therefore, inthis study, we aimed to compare in vivo performancesof macroporous (fabricated using stereolithography), microporous (fabricatedusing emulsion templating), and multiscale porous (fabricated usingemulsion templating and perforation) scaffolds made of 4PCLMA. Also,3D-printed macroporous scaffolds (fabricated using fused depositionmodeling) made of thermoplastic polycaprolactone were used as a control.Scaffolds were implanted into a critical-sized calvarial defect, animalswere sacrificed 4 or 8 weeks after implantation, and the new boneformation was assessed by micro-computed tomography, dental radiography,and histology. Multiscale porous scaffolds that include both micro-and macropores resulted in higher bone regeneration in the defectarea compared to only macroporous or only microporous scaffolds. Whenone-grade porous scaffolds were compared, microporous scaffolds showedbetter performance than macroporous scaffolds in terms of mineralizedbone volume and tissue regeneration. Micro-CT results revealed thatwhile bone volume/tissue volume (Bv/Tv) values were 8 and 17% at weeks4 and 8 for macroporous scaffolds, they were significantly higherfor microporous scaffolds, with values of 26 and 33%, respectively.Taken together, the results reported in this study showed the potentialapplication of multiscale PolyHIPE scaffolds, in particular, as apromising material for bone regeneration.en_US
dc.description.sponsorshipWe acknowledge the Medical Research Council (grant no. MR/L012669/1), the Engineering and Physical Sciences Research Council (grant no. EP/I007695/1), the Department of Scientific Research Projects of Izmir Institute of Technology (IZTECH-BAP, 2021-IYTE-1-0110 and 2022-IIYTE-2-0025), Health Institutes of Turkey (TUSEB-2022B02-22517), National Science and Technology Council (MOST107-2314-B-016-020), Medical Affairs Bureau Ministry of National Defense (MAB-107-056), and Tri-Service General Hospital (TSGH-C108-031). F.C. also thanks the Royal Society for funding a Royal Society Leverhulme Trust Senior Research Fellowship 2022 (SRF\R1\221053). B.A.D. and S.D. also acknowledge IzTech Integrated Research Centers (IzTech IRC), the Center for Materials Research.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Applied Materials & Interfacesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolycaprolactoneen_US
dc.subjectEmulsion templatingen_US
dc.subject3D printingen_US
dc.subjectStereolithographyen_US
dc.subjectBone tissue engineeringen_US
dc.subjectMultiscale porosityen_US
dc.subjectTemplated Scaffoldsen_US
dc.titleIn vivo bone regeneration capacity of multiscale porous polycaprolactone-based high internal phase emulsion (PolyHIPE) scaffolds in a rat calvarial defect modelen_US
dc.typeArticleen_US
dc.authorid0000-0002-5516-469X-
dc.authorid0000-0001-9933-5254-
dc.institutionauthorAldemir Dikici, Betültr
dc.institutionauthorDikici, Serkantr
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume15en_US
dc.identifier.issue23en_US
dc.identifier.startpage27696en_US
dc.identifier.endpage27705en_US
dc.identifier.wosWOS:001008292700001en_US
dc.identifier.scopus2-s2.0-85162886355en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr
dc.identifier.doi10.1021/acsami.3c04362-
dc.identifier.pmid37253168en_US
dc.authorscopusid57188877982-
dc.authorscopusid57207989855-
dc.authorscopusid57188879686-
dc.authorscopusid7401986384-
dc.authorscopusid55987061100-
dc.identifier.scopusqualityQ1-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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