Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13606
Title: Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation
Authors: Dongiovanni, Paola
Meroni, Marica
Casati, Sara
Goldoni, Riccardo
Thomaz, Douglas Vieira
Kehr, Nermin Seda
Galimberti, Daniela
Keywords: C-reactive protein
Proteins
Biosensors
Oxidative stress
Issue Date: 2023
Publisher: Springer
Abstract: Several chronic disorders including type 2 diabetes (T2D), obesity, heart disease and cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early assessment of chronic disorders encompass acute phase proteins (APP), cytokines and chemokines, pro-inflammatory enzymes, lipids and oxidative stress mediators. These substances enter saliva through the blood flow and, in some cases, there is a close relation between their salivary and serum concentration. Saliva can be easily collected and stored with non-invasive and cost-saving procedures, and it is emerging the concept to use it for the detection of inflammatory biomarkers. To this purpose, the present review aims to discuss the advantages and challenges of using standard and cutting-edge techniques to discover salivary biomarkers which may be used in diagnosis/therapy of several chronic diseases with inflammatory consequences with the pursuit to possibly replace conventional paths with detectable soluble mediators in saliva. Specifically, the review describes the procedures used for saliva collection, the standard approaches for the measurement of salivary biomarkers and the novel methodological strategies such as biosensors to improve the quality of care for chronically affected patients.
URI: https://doi.org/10.1038/s41368-023-00231-6
https://hdl.handle.net/11147/13606
ISSN: 1674-2818
2049-3169
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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