Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13676
Title: Targeted multidrug delivery systems to kill antibiotic-resistant Staphylococcus aureus
Authors: Özalp, Veli Cengiz
Ucak, Samet
Dursun, Ali D.
Sudağıdan, Mert
İçin, Öykü
Ahmetoğlu, Çekdar Vakıf
Henning, Laura M.
Simon, Ulla
Gurlo, Aleksander
Keywords: Antimicrobials
Aptamers
COK-12
Drug release
Ordered mesoporous silica
Issue Date: 2023
Publisher: Editions de Sante
Abstract: Different ordered mesoporous silica (OMS) nanoparticles, ranging from regular COK-12 to COK-12 modified in terms of pore shape and size, have been employed as standard drug carriers for the controlled adsorption and release of drug molecules in comparison to well-known OMS SBA-15 and MCM-41. The cytotoxicity analysis demonstrated that regular COK-12 particles were less harmful to mammalian cultured cells, causing lower apoptosis induction than modified COK-12, MCM-41, and SBA-15 particles. Thus, regular COK-12 was further used to prepare a dual antibiotic-loaded drug delivery material, followed by surface functionalization with Staphylococcus aureus-specific aptamers for targeting. The results demonstrated that the joint loading of lysozyme and vancomycin in regular COK-12 improved the ability of the antibiotic treatments to kill methicillin-resistant Staphylococcus strains via aptamer targeting. The minimum inhibitory concentration (MIC) values decreased 4.1-fold and 12-fold compared to the non-targeted use of the antimicrobial agents in homogeneous solutions for vancomycin and lysozyme, respectively, clearly demonstrating the high potential of COK-12 to be used as a carrier in multidrug therapy. © 2023 Elsevier B.V.
URI: https://doi.org/10.1016/j.jddst.2023.104622
https://hdl.handle.net/11147/13676
ISSN: 1773-2247
Appears in Collections:Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
1-s2.0-S1773224723004744-main.pdf
  Until 2025-01-01
5.26 MBAdobe PDFView/Open    Request a copy
Show full item record



CORE Recommender

Page view(s)

26
checked on Feb 26, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.