Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13767
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dc.contributor.authorTaşoğlu, Çağdaş-
dc.contributor.authorArslanoğlu, Alper-
dc.contributor.authorYalçın, Talat-
dc.date.accessioned2023-10-03T07:15:28Z-
dc.date.available2023-10-03T07:15:28Z-
dc.date.issued2023-
dc.identifier.issn1044-0305-
dc.identifier.issn1879-1123-
dc.identifier.urihttps://doi.org/10.1021/jasms.3c00049-
dc.identifier.urihttps://hdl.handle.net/11147/13767-
dc.description.abstractThefragmentation characteristics of b (7) ionsproduced from proline-containing heptapeptides have been studiedin detail. The study has utilized the following C-terminally amidatedmodel peptides: PA(6), APA(5), A(2)PA(4), A(3)PA(3), A(4)PA(2), A(5)PA, A(6)P, PYAGFLV, PAGFLVY, PGFLVYA, PFLVYAG,PLVYAGF, PVYAGFL, YPAGFLV, YAPGFLV, YAGPFLV, YAGFPLV, YAGFLPV, YAGFLVP,PYAFLVG, PVLFYAG, A(2)PXA(3), and A(2)XPA(3) (where X = C, D, F, G, L, V, and Y, respectively). The resultshave shown that b (7) ions undergo head-to-tailcyclization and form a macrocyclic structure. Under the collision-induceddissociation (CID) condition, it generates nondirect sequence ionsregardless of the position of the proline and the neighboring aminoacid residues. This study highlights the unusual and unique fragmentationbehavior of proline-containing heptapeptides. Following the head-to-tailcyclization, the ring opens up and places the proline residue in theN-terminal position while forming a regular oxazolone form of b (2) ions for all peptide series. Then, the fragmentationreaction pathway is followed by the elimination of proline with itsC-terminal neighbor residue as an oxazolone (e.g., PXoxa) for all proline-containing peptide series.en_US
dc.description.sponsorshipThe authors would like to acknowledge the support from the State Planning Organization (DPT) of Turkey for funding the Biological Mass Spectrometry and Proteomics Facility and National Mass Spectrometry Application and Research Center at Izmir Institute of Technology. We are indebted to the Scientific and Technological Research Council of Turkey (TUBITAK) for financial support of projects 109T430 and 112T558. C.T. wishes to thank the 2211 National Ph.D. Scholarship Program.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relationPeptit Türevlerinin Gaz Fazı Reaksiyon Mekanizmalarının Kütle Spektrometre İle İncelenmesitr
dc.relationProton Kopartılmış Peptit Türevlerinin Gaz Fazı Reaksiyon Mekanizmalarının Kütle Spektrometre İle İncelenmesitr
dc.relation.ispartofJournal of the American Society for Mass Spectrometryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProlineen_US
dc.subjectPeptide fragmentationen_US
dc.subjectScramblingof sequenceen_US
dc.subjectNondirect sequence ionsen_US
dc.subjectMacrocyclizationen_US
dc.subjectESI MS/MS mass spectrometryen_US
dc.titleGas phase fragmentation behavior of proline in macrocyclic b7 ionsen_US
dc.typeArticleen_US
dc.authorid0000-0002-5758-4743-
dc.authorid0000-0003-3780-702X-
dc.institutionauthorArslanoğlu, Alper-
dc.institutionauthorYalçın, Talattr
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume34en_US
dc.identifier.issue8en_US
dc.identifier.startpage1576en_US
dc.identifier.endpage1583en_US
dc.identifier.wosWOS:001022894100001en_US
dc.identifier.scopus2-s2.0-85164667488en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr
dc.identifier.doi10.1021/jasms.3c00049-
dc.identifier.pmid37402129en_US
dc.relation.grantno109T430-
dc.relation.grantno112T558-
dc.authorscopusid55022888800-
dc.authorscopusid8879717500-
dc.authorscopusid7003366439-
dc.authorwosidArslanoglu, Alper/F-1124-2011-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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