Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13769
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dc.contributor.authorKommineni, Nagavendra-
dc.contributor.authorChaudhari, Ruchita-
dc.contributor.authorConde, Joao-
dc.contributor.authorTamburacı, Sedeftr
dc.contributor.authorCecen, Berivan-
dc.contributor.authorChandra, Pranjal-
dc.contributor.authorPrasad, Rajendra-
dc.date.accessioned2023-10-03T07:15:29Z-
dc.date.available2023-10-03T07:15:29Z-
dc.date.issued2023-
dc.identifier.issn2373-9878-
dc.identifier.urihttps://doi.org/10.1021/acsbiomaterials.3c00510-
dc.identifier.urihttps://hdl.handle.net/11147/13769-
dc.description.abstractEngineered liposomal nanoparticles have unique characteristicsas cargo carriers in cancer care and therapeutics. Liposomal theranosticshave shown significant progress in preclinical and clinical cancermodels in the past few years. Liposomal hybrid systems have not onlybeen approved by the FDA but have also reached the market level. Nanosizedliposomes are clinically proven systems for delivering multiple therapeuticas well as imaging agents to the target sites in (i) cancer theranosticsof solid tumors, (ii) image-guided therapeutics, and (iii) combinationtherapeutic applications. The choice of diagnostics and therapeuticscan intervene in the theranostics property of the engineered system.However, integrating imaging and therapeutics probes within lipidself-assembly liposome may compromise their overalltheranostics performance. On the other hand, liposomal systems sufferfrom their fragile nature, site-selective tumor targeting, specificbiodistribution and premature leakage of loaded cargo molecules beforereaching the target site. Various engineering approaches, viz., grafting,conjugation, encapsulations, etc., have been investigated to overcomethe aforementioned issues. It has been studied that surface-engineeredliposomes demonstrate better tumor selectivity and improved therapeuticactivity and retention in cells/or solid tumors. It should be notedthat several other parameters like reproducibility, stability, smoothcirculation, toxicity of vital organs, patient compliance, etc. mustbe addressed before using liposomal theranostics agents in solid tumorsor clinical models. Herein, we have reviewed the importance and challengesof liposomal medicines in targeted cancer theranostics with theirpreclinical and clinical progress and a translational overview.en_US
dc.description.sponsorshipR.P. thanks the director of IIT-BHU, Varanasi, U.P., for encouraging and providing the necessary facility and support and would also like to thank the school of biochemical engineering, IIT-BHU. N.K. would like to thank CBR, Population Council, for providing the Sheldon J. Segal Post-Doctoral Fellowship. P.C. acknowledges the support from the DST-funded I-DAPT Hub Foundation, IIT BHU [DST/NMICPS/TIH11/IIT(BHU)2020/02]. The authors thank Leander Corrie, Arun Butreddy, Sachin Kumar, and Qing He for reading this manuscript. J.C. acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). The author dedicates this article to Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. All reproduced images and figures have been cited in this review.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Biomaterials Science and Engineeringen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiposomesen_US
dc.subjectInterventional theranosticen_US
dc.subjectSolid tumorsen_US
dc.subjectNanoimagingen_US
dc.titleEngineered liposomes in interventional theranostics of solid tumorsen_US
dc.typeReviewen_US
dc.authorid0000-0003-3234-226X-
dc.institutionauthorTamburacı, Sedeftr
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume9en_US
dc.identifier.issue8en_US
dc.identifier.startpage4527en_US
dc.identifier.endpage4557en_US
dc.identifier.wosWOS:001029698700001en_US
dc.identifier.scopus2-s2.0-85166769715en_US
dc.relation.publicationcategoryDiğertr
dc.identifier.doi10.1021/acsbiomaterials.3c00510-
dc.identifier.pmid37450683en_US
dc.authorscopusid57194060362-
dc.authorscopusid58523336800-
dc.authorscopusid56992468300-
dc.authorscopusid57194413931-
dc.authorscopusid24461480700-
dc.authorscopusid42961281300-
dc.authorscopusid57077644900-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
item.grantfulltextopen-
item.openairetypeReview-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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