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https://hdl.handle.net/11147/13771
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Argıtekin, Eda | - |
dc.contributor.author | Ersöz-Gülseven, Esra | - |
dc.contributor.author | Çakan-Akdoğan, Gülçin | - |
dc.contributor.author | Akdoğan, Yaşar | - |
dc.date.accessioned | 2023-10-03T07:15:30Z | - |
dc.date.available | 2023-10-03T07:15:30Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.issn | 1526-4602 | - |
dc.identifier.uri | https://doi.org/10.1021/acs.biomac.3c00363 | - |
dc.identifier.uri | https://hdl.handle.net/11147/13771 | - |
dc.description.abstract | V(III) instead of commonly used Fe(III) provided a richtris-catechol-metalcoordination at pH 7.4, which is important for slow drug release atphysiological pH. Bovine serum albumin (BSA) functionalized with catechol-containingdopamine (D) and cross-linked using tris-catechol-V(III) coordinationyielded pH-responsive compact D-BSA NPs (253 nm). However, conversionto bis- and/or mono-catechol-V(III) complexes in an acidic mediumresulted in degradation of NPs and rapid release of doxorubicin (DOX).It was shown that D-BSA NPs entered cancerous MCF-7 cells (66%) moreefficiently than non-cancerous HEK293T (33%) in 3 h. Also, DOX-loadedNPs reduced cell viability of MCF-7 by 75% and induced apoptosis ina majority of cells after 24 h. Biodegradability and lack of hemolyticactivity were shown in vitro, whereas a lack of toxicity was shownin histological sections of zebrafish. Furthermore, 30% of circulatingtumor cells in vasculature in 24 h were killed by DOX-loaded NPs shownwith the zebrafish CTC xenograft model. | en_US |
dc.description.sponsorship | Health Institute of Turkey via 2022-ACIL-01-A Program; [11975] | en_US |
dc.description.sponsorship | This work was financially supported by Health Institute of Turkey via 2022-ACIL-01-A Program under grant 11975. The authors thank IZTECH Center for Materials Research, IZTECH Biotechnology, and Bioengineering Research Center, IZTECH Environmental Development Application and Research Center, IBG Optic Imaging Core Facility, IBG Histopathology Core Facility and IBG Zebrafish Facility, and Emine Gelinci for technical support. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Amer Chemical Soc | en_US |
dc.relation.ispartof | Biomacromolecules | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | CROSS-LINKING | en_US |
dc.subject | BOUND PACLITAXEL | en_US |
dc.subject | BSA NANOPARTICLES | en_US |
dc.subject | PROTEIN FILMS | en_US |
dc.subject | CANCER | en_US |
dc.subject | MICROENVIRONMENT | en_US |
dc.subject | RELEASE | en_US |
dc.subject | ANTIOXIDANT | en_US |
dc.subject | TRANSPORT | en_US |
dc.subject | KINETICS | en_US |
dc.title | Dopamine-Conjugated Bovine Serum Albumin Nanoparticles Containing pH-Responsive Catechol-V(III) Coordination for In Vitro and In Vivo Drug Delivery | en_US |
dc.type | Article | en_US |
dc.authorid | Ersoz Gulseven, Esra/0000-0003-2541-9388 | - |
dc.authorid | Cakan Akdogan, Gulcin/0000-0002-6356-5979 | - |
dc.institutionauthor | … | - |
dc.department | İzmir Institute of Technology | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 3603 | en_US |
dc.identifier.endpage | 3618 | en_US |
dc.identifier.wos | WOS:001029699700001 | en_US |
dc.identifier.scopus | 2-s2.0-85166552296 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1021/acs.biomac.3c00363 | - |
dc.identifier.pmid | 37450837 | en_US |
dc.authorscopusid | 58520629500 | - |
dc.authorscopusid | 58519898900 | - |
dc.authorscopusid | 24922534100 | - |
dc.authorscopusid | 13805842900 | - |
dc.authorwosid | Cakan Akdogan, Gulcin/GRO-6030-2022 | - |
dc.identifier.wosquality | Q1 | - |
dc.identifier.scopusquality | Q1 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 03.09. Department of Materials Science and Engineering | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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