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Title: Molecular separation by using active and passive microfluidic chip designs: A comprehensive review
Authors: Ebrahimi, Aliakbar
İçöz, Kutay
Didarian, Reza
Shih, Chih-Hsin
Tarım, Ergün Alperay
Nasseri, Behzad
Akpek, Ali
Çeçen, Berivan
Bal Öztürk, Ayça
Güleç, Kadri
Ethan Li, Yi-Chen
Shih, Steven
Tarım, Burcu Sırma
Tekin, Hüseyin Cumhur
Keywords: Active separation
Biomolecule separation
Hybrid separation
Passive separation
Publisher: Wiley
Abstract: Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab-on-a-chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques. © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.
ISSN: 2196-7350
Appears in Collections:Bioengineering / Biyomühendislik
Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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