Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14157
Title: Lymphedema after Sentinel Lymph Node Biopsy: Who Is at Risk?
Authors: Isik, A.
Soran, A.
Grasi, A.
Barry, N.
Sezgin, E.
Keywords: breast
edema
lymph
adult
aging
Article
axillary lymph node dissection
body mass
breast cancer
cancer adjuvant therapy
cancer hormone therapy
cancer radiotherapy
cancer staging
controlled study
disease course
female
follow up
human
human tissue
incidence
lymphedema
major clinical study
middle aged
postoperative complication
preoperative evaluation
retrospective study
risk factor
sentinel lymph node biopsy
adverse event
breast tumor
lymphedema
pathology
procedures
prospective study
sentinel lymph node biopsy
Breast Neoplasms
Female
Humans
Lymphedema
Prospective Studies
Retrospective Studies
Sentinel Lymph Node Biopsy
Publisher: Mary Ann Liebert Inc.
Abstract: Background: Sentinel lymph node biopsy (SLNB) is the accepted approach to stage the clinically negative axilla. The incidence of lymphedema (LE) after SLNB is about 5%. We hypothesize that patients undergoing axillary excision of >5 lymph nodes (LNs) are at increased risk of developing LE. Methods and Results: A single institution prospective breast cancer database was retrospectively reviewed from January 2013 to December 2017, to identify patients who underwent SLNB and were diagnosed with LE. Inclusion criteria was (1) de novo breast cancer, (2) SLNB in clinically node negative patients, and (3) no preoperative diagnosis LE of an extremity. Exclusion criteria was history of axillary lymph node dissection. Age, body mass index, tumor-node-metastasis status, surgery type, neoadjuvant or adjuvant chemotherapy, radiotherapy, and hormone therapy were analyzed. Of the 3325 patients identified, 2940 patients met the inclusion criteria and were included in the final analysis. Median follow-up time was 24 months. Forty-seven (2%) patients were diagnosed with LE, and nine patients (19%) had >5 LNs excised. LE was diagnosed in 3.7% of patients who had >5 LNs excised versus 1.4% of patients with ≤5 LNs excised. Incidence of LE was higher in patients with >5 LNs excision (p = 0.006). Conclusion: Our study showed that patients have a higher likelihood of developing LE when >5 LNs are excised. © Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.
URI: https://doi.org/10.1089/lrb.2020.0093
https://hdl.handle.net/11147/14157
ISSN: 1539-6851
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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