Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14160
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dc.contributor.authorÇevik, Merve-
dc.contributor.authorDikici, Serkan-
dc.date.accessioned2024-01-06T07:22:28Z-
dc.date.available2024-01-06T07:22:28Z-
dc.date.issued2023-
dc.identifier.issn1744-683X-
dc.identifier.urihttps://doi.org/10.1039/d3sm01236k-
dc.identifier.urihttps://hdl.handle.net/11147/14160-
dc.description.abstractCardiovascular diseases are mostly associated with narrowing or blockage of blood vessels, and it is the most common cause of death worldwide. The use of vascular grafts is a promising approach to bypass or replace the blocked vessels for long-term treatment. Although autologous arteries or veins are the most preferred tissue sources for vascular bypass, the limited presence and poor quality of autologous vessels necessitate seeking alternative biomaterials. Recently, synthetic grafts have gained attention as an alternative to autologous grafts. However, the high failure rate of synthetic grafts has been reported primarily due to thrombosis, atherosclerosis, intimal hyperplasia, or infection. Thrombosis, the main reason for failure upon implantation, is associated with damage or absence of endothelial cell lining in the vascular graft's luminal surface. To overcome this, tissue-engineered vascular grafts (TEVGs) have come into prominence. Alongside the well-established scaffold manufacturing techniques, decellularized plant-based constructs have recently gained significant importance and are an emerging field in tissue engineering and regenerative medicine. Accordingly, in this study, we demonstrated the fabrication of tubular scaffolds from decellularized parsley stems and recellularized them with human endothelial cells to be used as a potential TEVG. Our results suggested that the native plant DNA was successfully removed, and soft tubular biomaterials were successfully manufactured via the chemical decellularization of the parsley stems. The decellularized parsley stems showed suitable mechanical and biological properties to be used as a TEVG material, and they provided a suitable environment for the culture of human endothelial cells to attach and create a pseudo endothelium prior to implantation. This study is the first one to demonstrate the potential of the parsley stems to be used as a potential TEVG biomaterial. © 2024 The Royal Society of Chemistry.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofSoft Matteren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiocompatibilityen_US
dc.subjectBlood vesselsen_US
dc.subjectFailure analysisen_US
dc.subjectAutologous graftsen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectCauses of deathen_US
dc.subjectVascular graftsen_US
dc.subjectEndothelial cellsen_US
dc.titleDevelopment of tissue-engineered vascular grafts from decellularized parsley stemsen_US
dc.typeArticleen_US
dc.authorid0000-0001-9933-5254-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:001125514900001en_US
dc.identifier.scopus2-s2.0-85179834719en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1039/d3sm01236k-
dc.authorscopusid58764194400-
dc.authorscopusid57188879686-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextembargo_20250101-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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