Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14201
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dc.contributor.authorBayram, N.N.-
dc.contributor.authorUlu, G.T.-
dc.contributor.authorTopuzoğulları, M.-
dc.contributor.authorBaran, Y.-
dc.contributor.authorDinçer, İşoğlu, S.-
dc.date.accessioned2024-01-06T07:22:36Z-
dc.date.available2024-01-06T07:22:36Z-
dc.date.issued2022-
dc.identifier.issn1616-5187-
dc.identifier.urihttps://doi.org/10.1002/mabi.202100375-
dc.identifier.urihttps://hdl.handle.net/11147/14201-
dc.description.abstractHere, a targeted, dual-pH responsive, and stable micelle nanocarrier is designed, which specifically selects an HER2 receptor on breast cancer cells. Intracellularly degradable and stabilized micelles are prepared by core cross-linking via reversible addition−fragmentation chain-transfer (RAFT) polymerization with an acid-sensitive cross-linker followed by the conjugation of maleimide–doxorubicin to the pyridyl disulfide-modified micelles. Multifunctional nanocarriers are obtained by coupling HER2-specific peptide. Formation of micelles, addition of peptide and doxorubicin (DOX) are confirmed structurally by spectroscopical techniques. Size and morphological characterization are performed by Zetasizer and transmission electron microscope (TEM). For the physicochemical verification of the synergistic acid-triggered degradation induced by acetal and hydrazone bond degradation, Infrared spectroscopy and particle size measurements are used. Drug release studies show that DOX release is accelerated at acidic pH. DOX-conjugated HER2-specific peptide-carrying nanocarriers significantly enhance cytotoxicity toward SKBR-3 cells. More importantly, no selectivity toward MCF-10A cells is observed compared to HER2(+) SKBR-3 cells. Formulations cause apoptosis depending on Bax and Caspase-3 and cell cycle arrest in G2 phase. This study shows a novel system for HER2-targeted therapy of breast cancer with a multifunctional nanocarrier, which has higher stability, dual pH-sensitivity, selectivity, and it can be an efficient way of targeted anticancer drug delivery. © 2021 Wiley-VCH GmbHen_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 116R057; Hacettepe Üniversitesien_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell deathen_US
dc.subjectControlled drug deliveryen_US
dc.subjectDiseasesen_US
dc.subjectInfrared spectroscopyen_US
dc.subjectLiving polymerizationen_US
dc.subjectParticle sizeen_US
dc.subjectPeptidesen_US
dc.subjectpH sensorsen_US
dc.subjectSulfur compoundsen_US
dc.subjectTargeted drug deliveryen_US
dc.subjectTransmission electron microscopyen_US
dc.subjectBreast Canceren_US
dc.subjectCross-linked micellesen_US
dc.subjectDoxorubicinen_US
dc.subjectDual ph-responsivenessen_US
dc.subjectHER2 targetingen_US
dc.subjectMicelle nanocarrieren_US
dc.subjectMultifunctional nanocarrieren_US
dc.subjectNanocarriersen_US
dc.subjectPh responsivenessen_US
dc.subjectReversible addition-fragmentation chain transfer polymerizationen_US
dc.subjectMicellesen_US
dc.subjectantineoplastic agenten_US
dc.subjectdoxorubicinen_US
dc.subjectdrug carrieren_US
dc.subjectchemistryen_US
dc.subjectdrug releaseen_US
dc.subjecthumanen_US
dc.subjectmicelleen_US
dc.subjectpHen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectDoxorubicinen_US
dc.subjectDrug Carriersen_US
dc.subjectDrug Liberationen_US
dc.subjectHumansen_US
dc.subjectHydrogen-Ion Concentrationen_US
dc.subjectMicellesen_US
dc.titleHER2-Targeted, Degradable Core Cross-Linked Micelles for Specific and Dual pH-Sensitive DOX Releaseen_US
dc.typeArticleen_US
dc.institutionauthor-
dc.departmentİzmir Institute of Technologyen_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85118678301en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/mabi.202100375-
dc.identifier.pmid34708562en_US
dc.authorscopusid57325811500-
dc.authorscopusid57215384419-
dc.authorscopusid16744519800-
dc.authorscopusid9636164400-
dc.authorscopusid55751559400-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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