Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14371
Title: Gangliosides as Therapeutic Targets for Neurodegenerative Diseases
Authors: Inci, Orhan Kerim
Basirli, Hande
Can, Melike
Yanbul, Selman
Seyrantepe, Volkan
Keywords: [No Keyword Available]
Publisher: Hindawi Ltd
Abstract: Gangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP). In this review, we summarized not only the critical roles of biosynthetic enzymes and their inhibitors in ganglioside metabolism but also the efficacy of treatment strategies of ganglioside to address their significance in those diseases.
URI: https://doi.org/10.1155/2024/4530255
https://hdl.handle.net/11147/14371
ISSN: 2090-3030
2090-3049
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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